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The overall objective of Dr. Daniel Gonzalez’s research program is to optimize pharmacotherapeutic efficacy and safety through the use of clinical and experimental data, and the application of mathematical modeling and simulation techniques, with an emphasis in pediatric populations. This is first accomplished by characterizing the differences in pharmacokinetic (PK) and pharmacodynamic (PD) relationships across human development, elucidating and quantifying influential factors of drug disposition, and the degree of interindividual variability surrounding them. Assessment of such changes are then related to deviations in drug effects and overall patient outcomes. With such characterizations established, optimal dosing regimens are derived, with a clinical impact in patient populations for which evidence-based dosing recommendations are frequently absent.
The Gonzalez Lab is currently focused on research in the following areas:
Characterizing drug pharmacokinetics/pharmacodynamics in the pediatric population
Studying the effect of obesity on pharmacokinetics and drug dosing in children and adolescents
Evaluating drug-drug interactions in the pediatric population
Use of real-world data to evaluate drug safety and efficacy
Drug dosing individualization
研究兴趣
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Stephen J. Balevic,Daniel Weiner,Christoph P. Hornik,Michael Cohen-Wolkowiez,Daniel Gonzalez,Xiaoming Wang,Meixiang Xu, Sherif Z. Abdel-Rahman,Erik Rytting
JOURNAL OF CLINICAL PHARMACOLOGY (2024)
Elizabeth J. Thompson,Kanecia O. Zimmerman,Daniel Gonzalez,Henry P. Foote, Sangah Park,Kevin D. Hill, Jillian H. Hurst,Chi D. Hornik,Reid C. Chamberlain,Rasheed A. Gbadegesin,Christoph P. Hornik
Sean McCann, Victória E Helfer, Stephen J Balevic,Chi D Hornik,Stuart L Goldstein, Julie Autmizguine, Marisa Meyer,Amira Al-Uzri, Sarah G Anderson,Elizabeth H Payne, Sitora Turdalieva,Daniel Gonzalez,
Journal of clinical pharmacology (2024)
Journal of clinical pharmacology (2024)
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 4 (2023): 762-767
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