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Cancer research and treatment is currently undergoing a revolution whereby an individual cancer can be treated as a molecular disease rather than an organ-specific disease. Many different molecular therapies have been developed which can be used for “precision medicine” or “personalized therapy”. To be successful, these approaches require a detailed molecular understanding of the genetic alterations that are responsible for each individual cancer.
The major focus of our lab is understanding “driver genes” of human cancer using cell biological, biochemical, and mass spec techniques. Many of our projects examine Receptor Tyrosine Kinases (RTKs), important signaling molecules that have evolved to transduce extracellular signals across the cellular membrane to activate intracellular pathways. Unfortunately, these same receptors may become abnormally activated, either by somatic point mutations or chromosomal translocations, resulting in cancer. Our lab is relatively small, highly focused, and very interactive.
The major focus of our lab is understanding “driver genes” of human cancer using cell biological, biochemical, and mass spec techniques. Many of our projects examine Receptor Tyrosine Kinases (RTKs), important signaling molecules that have evolved to transduce extracellular signals across the cellular membrane to activate intracellular pathways. Unfortunately, these same receptors may become abnormally activated, either by somatic point mutations or chromosomal translocations, resulting in cancer. Our lab is relatively small, highly focused, and very interactive.
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Growth Regulation and Carcinogenesispp.19-30, (2020)
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