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个人简介
The Human Immunology Section (HIS) studies the processes that determine the course of human diseases in which the immune system plays a central role in their pathogenesis and outcome. We take a systems biology approach to generate multi-scale datasets. Our overriding philosophy is to address questions of human disease directly in humans and use the knowledge gained to initiate clinical studies of new therapeutic and vaccine approaches.
Our studies of HIV explore the cellular and molecular mechanisms by which the virus is acquired and disease progression is maintained, with an emphasis on host genetic and microbiological factors that render an individual vulnerable to infection. We explore the relationships among target cell types and availability as the reservoir for HIV, systemic inflammation, lymphoid tissue architecture, the gastrointestinal mucosal barrier and the individual's 'pathogen burden' in determining the rate of disease progression. We extend our understanding of the relationship between the host microbiome, systemic inflammation and immune system functionality to other infectious and non-infectious disease states and responses to vaccination.
Our studies of HIV explore the cellular and molecular mechanisms by which the virus is acquired and disease progression is maintained, with an emphasis on host genetic and microbiological factors that render an individual vulnerable to infection. We explore the relationships among target cell types and availability as the reservoir for HIV, systemic inflammation, lymphoid tissue architecture, the gastrointestinal mucosal barrier and the individual's 'pathogen burden' in determining the rate of disease progression. We extend our understanding of the relationship between the host microbiome, systemic inflammation and immune system functionality to other infectious and non-infectious disease states and responses to vaccination.
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论文共 500 篇作者统计合作学者相似作者
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Journal of Virologypp.e0120423-e0120423, (2024)
Timothy S. Johnston, Shuk Hang Li,Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek,David B. Reeg,Daniel C. Douek, E. John Wherry,Scott E. Hensley
Immunityno. 4 (2024): 912-925.e4
Cell Reportsno. 2 (2024): 113706-113706
Inga Rimkute,Natthawan Chaimongkol,Kamron D. Woods,Bianca M. Nagata,Samuel Darko, Sucheta Gudbole,Amy R. Henry,Stanislav V. Sosnovtsev,Adam S. Olia,Raffaello Verardi,Karin Bok,John-Paul Todd,
Marie Materna,Ottavia M Delmonte,Marita Bosticardo,Mana Momenilandi,Peyton E Conrey,Bénédicte Charmeteau-De Muylder,Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm,Frederik Staels, Christian A Ganoza,Samuel Darko,
Science (New York, N.Y.)no. 6686 (2024): eadh4059-eadh4059
Developmental and comparative immunology (2024): 105149-105149
Madhu Prabhakaran, Flavio Matassoli,David Leggat, Abigayle Hoover, Abhinaya Srikanth, Weiwei Wu,Amy R. Henry,Jennifer Wang,Bob C. Lin,I-Ting Teng,Chaim A. Schramm,Mike Castro,
SCIENCE TRANSLATIONAL MEDICINEno. 728 (2024): eadd5960-eadd5960
Shilpi Jain,Sanjeev Kumar,Lilin Lai,Susanne Linderman, Ansa A Malik,Madison L Ellis,Sucheta Godbole,Daniel Solis,Malaya K Sahoo, Kareem Bechnak, Isabel Paredes, Ralph Tanios,
bioRxiv : the preprint server for biology (2024)
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