基本信息
浏览量:10
职业迁徙
个人简介
Dr. Brat directs a basic and translational research lab that investigates mechanisms of glioma progression, including the contributions of hypoxia, genetics, tumor microenvironment and stem cells. Glioma progression is characterized by tumor necrosis, severe hypoxia and angiogenesis. One project investigates mechanisms that cause hypoxia and has focused on vaso-occlusion and intravascular thrombosis that are thought to be initiated by tissue factor, a highly potent pro-coagulant. His lab is studying how the reshaping of the tumor micro-environment leads to accelerated tumor growth and how the enrichment of glioma stem cells and influx of tumor associated macrophages may promote this. His lab also studies mechanisms that confer specialized biologic properties to glioma stem cells (GSC) in GBM, including their ability to divide asymmetrically, their tendency to home to hypoxic micro-environments and their resistance to therapy. The Drosophila brain tumor (brat) gene normally regulates asymmetric cellular division and neural progenitor differentiation in the CNS of flies and, when mutated, leads to a massive brain containing only neuroblastic cells with tumor-like properties. The human homolog of Drosophila brat, Trim3, is under investigation for its role in regulating asymmetric cell division and stem-like properties in GSCs. We are currently investigating those gene products that antagonize the tumor promoting effects of Brat/Trim3 loss on brain tumor development and are focused on CDK5/p35 based on the results of a genetic screen. Dr. Brat has over 20 years of experience in brain tumor research and has written more than 300 peer-reviewed manuscripts and reviews. In the laboratory setting, he has trained over 50 students, residents and fellows and has received major awards for mentoring.
研究兴趣
论文共 239 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
AMERICAN JOURNAL OF CANCER RESEARCHno. 9 (2023): 4222-+
引用0浏览0WOS引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn