基本信息
浏览量:0
职业迁徙
个人简介
Research interests
Only a small amount of the genome contains genes that code for proteins. In fact, much of the genome is transcribed into RNA, but the importance of these non-coding RNAs is only just becoming clear. Our research focuses on the mechanism of enhancer RNAs (eRNAs), non-protein coding RNAs transcribed from enhancers. Enhancers are non-coding genetic regulatory elements that regulate cell-type specific gene expression in metazoans; in humans, enhancers are hotspots for mutations in a number of diseases.
We look at how the unique sequence and structure of eRNAs allows them to control gene expression in enhancer-specific ways and what happens when this process goes wrong, for example in diseases such as ALS where enhancers are hotspots for mutations. We integrate multidisciplinary techniques such as cryo-EM with molecular biology and functional genomics approaches to build a picture of diverse features of eRNA function and how they interact with the epigenetic-machines that control gene expression across a variety of scales.
研究兴趣
论文共 3 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Katie Gelder,Daniel Bose
BioEssays : news and reviews in molecular, cellular and developmental biologyno. 10 (2023)
引用0浏览0WOS引用
0
0
Laura J. Harrison,Daniel Bose
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn