Daniel Winer
副教授
Department of Laboratory Medicine & Pathobiology
Temerty Faculty of Medicine, University of Toronto;Buck Institute for Research on Aging;Department of Pathology, University Health Network;Division of Advanced Diagnostics - Metabolism, Toronto General Research Institute
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个人简介
The goal of our laboratory is to better understand how the immune system influences physiological processes and contributes to disease, with the aim of using this information to develop new translational diagnostics and therapeutics, including preventative vaccination strategies.
Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.
Our primary research focus is to elucidate immune mediated pathways governing obesity related insulin resistance. Obesity and its major complications, including insulin resistance, are a major global cause of morbidity and mortality, and have reached epidemic proportions. Evidence is mounting that a significant contributing cause of insulin resistance is chronic inflammation in visceral adipose tissue (VAT). This inflammation was initially thought to be driven solely by macrophages of the innate immune system attracted to dying adipocytes in fat. Recently, in collaboration with the Hospital for Sick Children and Stanford University, we have demonstrated that the adaptive immune system, including T cells, B cells and the antibodies they produce, play a significant and active role in regulating this process. This work has introduced a new " autoimmune" component to obesity related insulin resistance, and has led to new ways in thinking about metabolic disease. We continue to investigate immune mediated mechanisms in obesity and diabetes with the aim of translating our findings to help the many people afflicted by these diseases.
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Priya Makhijani,Rohini Emani,Carlos Galicia Aguirre, Wei-Chieh Mu,Anand Rane, Jenny Hong Yu Ng, Taylor R Valentino, Max Manwaring-Mueller, Christopher Ryan Tan,Huixun Du, Fei Wu,Saad Khan,
bioRxiv : the preprint server for biology (2024)
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bioRxiv : the preprint server for biology (2023)
Kasia Dzierlega,Mainak Chakraborty,Megan Lee, Amro M. Soliman, Derek Parker,Saad Khan,Yi Tao Chan,Masoud Akbari,Toshifumi Yokota,Shawn Winer, Kristi Baker,Sue Tsai,
JOURNAL OF IMMUNOLOGYno. 3 (2023): 497-507
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Molecular metabolism (2023): 101755-101755
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