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职业迁徙
个人简介
He received his PhD with honors from Leiden University in 2009 and is specialized in cardiac electrophysiology, atrial & ventricular arrhythmias and synthetic biomedicine (which he defines as the creation of new biology for therapeutic purposes). One of the main aims of his group is to develop biological therapies for cardiac diseases, in particular cardiac arrhythmias, allowing the heart itself to detect and neutralize physiological disturbances. Here, cardiac optogenetics, i.e. forced expression of light-sensitive proteins and their subsequent activation by light to modulate cardiac function at unmatched spatiotemporal resolution, is one of the key means of investigation. Also, different models of cardiomyogenic differentiation are used to investigate how excitability and intercellular electrical communication is established and (dys)regulated in order to use these insights for synthetic biomedical purposes, i.e. generative medicine.
研究兴趣
论文共 173 篇作者统计合作学者相似作者
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COMPUTERS IN BIOLOGY AND MEDICINE (2024): 107949-107949
Journal of internal medicineno. 3 (2023): 347-357
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S. Deng,V. Portero, B. L. Den Ouden, C. I. Bart, W. H. Bax, X. Hu, A. A. F. De Vries, G. Q. Zhang,D. A. Pijnappels
European Heart Journalno. Supplement_2 (2023)
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Balazs Ordog,Tim De Coster,Sven O. Dekker, Cindy I. Bart,Juan Zhang,Gerard J. J. Boink, Wilhelmina H. Bax, Shanliang Deng, Bram L. den Ouden, Antoine A. F. de Vries,Daniel A. Pijnappels
CELL REPORTS METHODSno. 12 (2023): 100671-100671
biorxiv(2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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