基本信息
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个人简介
RESEARCH
Cells & Protocells
The Hammer laboratory develops quantitative tools to analyze or mimic biology. We have particular interest in the role of cell adhesion and motility in the immune response. Also, we are interested in developing synthetic tools to mimic biology, such as making artificial cells (protocells) from synthetic, tunable materials.
CELL MOTILITY
After leukocytes dock at inflammatory sites, they crawl to their targets. These amoeboid cells crawl quickly but exert small forces. We have used traction force microscopy (TFM) and micropost arrays, combined with microfluidic gradient chambers, to image the forces that leukocytes exert during chemotaxis and chemokinesis. We have found that neutrophils exert their largest stresses in the rear while dendritic cells exert pulling forces from the front. We are now exploring how the internal molecular machinery of these cells is related to the force generation using knock-out mice and engineered cell lines.
Cells & Protocells
The Hammer laboratory develops quantitative tools to analyze or mimic biology. We have particular interest in the role of cell adhesion and motility in the immune response. Also, we are interested in developing synthetic tools to mimic biology, such as making artificial cells (protocells) from synthetic, tunable materials.
CELL MOTILITY
After leukocytes dock at inflammatory sites, they crawl to their targets. These amoeboid cells crawl quickly but exert small forces. We have used traction force microscopy (TFM) and micropost arrays, combined with microfluidic gradient chambers, to image the forces that leukocytes exert during chemotaxis and chemokinesis. We have found that neutrophils exert their largest stresses in the rear while dendritic cells exert pulling forces from the front. We are now exploring how the internal molecular machinery of these cells is related to the force generation using knock-out mice and engineered cell lines.
研究兴趣
论文共 407 篇作者统计合作学者相似作者
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Rachel M. Welles, Kandarp A. Sojitra,Mikael V. Garabedian,Boao Xia,Wentao Wang,Muyang Guan, Roshan M. Regy, Elizabeth R. Gallagher,Daniel A. Hammer,Jeetain Mittal,Matthew C. Good
Nature Chemistrypp.1-11, (2024)
Rachel M. Welles, Kandarp A. Sojitra,Mikael V. Garabedian,Boao Xia,Wentao Wang,Muyang Guan, Roshan M. Regy, Elizabeth R. Gallagher,Daniel A. Hammer,Jeetain Mittal,Matthew C. Good
NATURE CHEMISTRY (2024)
ACS applied materials & interfacesno. 44 (2023): 50799-50808
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Alexander Buffone Jr,Daniel A. Hammer,Sarah Hyun Ji Kim,Nicholas R. Anderson, Ai Mochida,Dong-Hun Lee, Subham Guin
Frontiers in Cell and Developmental Biology (2023): 1291201-1291201
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Rachel M Welles, Kandarp A Sojitra,Mikael V Garabedian,Boao Xia,Wentao Wang, Muyang Guan,Roshan M Regy, Elizabeth R Gallagher,Daniel A Hammer,Jeetain Mittal,Matthew C Good
biorxiv(2023)
Biophysical Journalno. 3 (2022): 146a-146a
The Biophysicistno. 1 (2021): 12-15
Handbook of Lipid Membranespp.323-336, (2021)
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