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Mammals use three distinct pathways for repairing chromosome breaks. Ramsden lab is interested in the mechanistic details of how each pathway works, but also how and why a given pathway is chosen, and the consequences of choosing the “wrong” pathway. Ramsden lab’s work has relevance to normal organismal development and aging, as well as carcinogenesis and cancer therapy. Notably, repair of chromosome breaks is also central to genome engineering.
Ramsden lab uses diverse approaches, including biochemical analyses and somatic cell genetics. Ramsden lab also work closely with a wide variety of labs with expertise in protein structure determination, biophysics, cell biology, and model organism genetics.
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论文共 132 篇作者统计合作学者相似作者
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Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li,Dale A. Ramsden,Richard D. Wood,Sylvie Doublié,Eli Rothenberg
NATUREno. 7988 (2023): 836-+
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2023): 41-42
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Environmental and molecular mutagenesis (2023)
Natureno. 7972 (2023): 218-225
Susanna Stroik,Juan Carvajal-Garcia,Dipika Gupta, Alyssa Edwards, Adam Luthman, David W Wyatt, Rachel L Dannenberg,Wanjuan Feng,Thomas A Kunkel,Gaorav P Gupta, Mark Hedglin, Richard Wood,
Natureno. 7988 (2023): 836-841
biorxiv(2022)
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