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个人简介
Dr. Stewart has made a number of seminal discoveries elucidating the importance of endothelial factors in health and disease, notably the role of the nitric oxide system in angiogenesis and of endothelin-1 in pulmonary hypertension. He is a leader in developing cell and gene based therapies for cardiovascular disease. He led the first Canadian clinical trial to test an angiogenic gene therapy using VEGF to try to stimulate heart repair in people who had suffered heart attacks.
Dr. Stewart spearheaded the world’s first clinical trial of a gene-enhanced cell therapy for pulmonary hypertension, using endothelial progenitor cells engineered to over-express the endothelial nitric oxide synthase. He has also launched the first enhanced progenitor cell therapy trial for post heart attack repair, and his research has led to a clinical trial that will assess whether mesenchymal stromal stem cells can improve outcomes for patients with septic shock.
研究兴趣
论文共 752 篇作者统计合作学者相似作者
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Sandrine Parent, Jennifer St Amant, Sophie Van Remortel, Saad Kahn, Ramana Vaka,David Courtman,Duncan John Stewart,Darryl Raymond Davis
JACC: Clinical Electrophysiology (2024)
Chanèle Cyr-Depauw,David P Cook, Ivana Mižik,Flore Lesage,Arul Vadivel,Laurent Renesme,Yupu Deng,Shumei Zhong,Pauline Bardin,Liqun Xu,Marius A. Möbius, Jenny Marzahn,
American Journal of Respiratory and Critical Care Medicine (2024)
Sandrine Parent, Jennifer St Amant, Sophie Van Remortel, Saad Kahn, Ramana Vaka,David Courtman,Duncan John Stewart,Darryl Raymond Davis
JACC: Clinical Electrophysiology (2024)
Eva Kuhar, Nikesh Chander,Duncan J Stewart, Forough Jahandideh,Haibo Zhang,Arnold S Kristof,Julie A Bastarache,Eric P Schmidt,Monica Taljaard,Bernard Thébaud,Doreen Engelberts,Dean A Fergusson,
American journal of physiology. Lung cellular and molecular physiology (2024)
STEM CELLS TRANSLATIONAL MEDICINE (2024)
Sandrine Parent, Ramana Vaka, Jennifer St Amant, Saad Kahn, Sophie Van Remortel, Christina Bi,David Courtman,Duncan John Stewart,Darryl Raymond Davis
Theranosticsno. 2 (2024): 608-621
Yupu Deng,Ketul R. Chaudhary,Anli Yang, Kirishani Kesavan,Liyuan Wang, Kevin Chathely,Duncan J. Stewart
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Duncan J Stewart, Albert Gianchetti,Dawn Byrnes,Howard C Dittrich, Barb Thorne, Linda L Manza, Rickey R Reinhardt
Nicholas D Cober,Emma McCourt, Rafael Soares Godoy,Yupu Deng, Ken Schlosser, Anu Situ,David P Cook,Sarah-Eve Lemay,Timothy Klouda,Ke Yuan,Sebastien Bonnet,Duncan J Stewart
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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