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Professor Skene and her team's research is directed towards characterisation and treatment of circadian rhythm sleep disorders as experienced by blind people, shift workers and older people. Her team's findings have led to the optimisation of melatonin (dose, time of administration) and light (wavelength, time of administration) to affect the human circadian clock. Prof Skene has pioneered studies on the spectral sensitivity of the human circadian axis, being one of the first to show the importance of short wavelength blue light. These results have important implications for the design and use of lighting in situations such as the treatment of circadian rhythm sleep disorders, adaptation to shift work as well as in work and living environments.
Currently Professor Skene's research team is studying the links between human circadian clocks, sleep and metabolism in health, circadian disorders and metabolic diseases (shift workers, Type 2 diabetes, liver disease). Investigating the effect of time of day, circadian clock, sleep and food influences on the human metabolome using targeted LC-MS metabolomics is currently a major focus.
Currently Professor Skene's research team is studying the links between human circadian clocks, sleep and metabolism in health, circadian disorders and metabolic diseases (shift workers, Type 2 diabetes, liver disease). Investigating the effect of time of day, circadian clock, sleep and food influences on the human metabolome using targeted LC-MS metabolomics is currently a major focus.
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European Journal of Nutritionno. 2 (2024): 527-537
Juliane Hannemann,Anika Laing,Benita Middleton,Edzard Schwedhelm, Nikolaus Marx,Massimo Federici, Mariola Kastner,Debra J. Skene,Rainer Boeger
PHARMACOLOGICAL RESEARCH (2024): 107011-107011
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