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职业迁徙
个人简介
My early research interests included studying the structural characteristics of variety of cell surface molecules associated with normal and malignant cellular phenotypes including CD34. My work studying the CD34 antigen led to the development of a new Flow Cytometric method to enumerate CD34+ cells.
In 1996 this method evolved into a clinical Guideline for ISHAGE (Int’l Soc Hematotherapy and Graft Evaluation). The ‘single platform’ variant of the ISHAGE Guidelines is the most widely used method Worldwide to assess graft adequacy in the Bone Marrow Transplant setting and is embodied in several National and International Guidelines for graft assessment by Flow Cytometry. This work led to the Wallace H. Coulter Distinguished Lecture Award in 2006, “to recognize lifetime contribution to the science, education and practice of Clinical Cytometry.”
As Technical Director of the UHN Clinical Flow Cytometry Laboratory at Toronto General Hospital, I develop new Flow Cytometric assays for deployment in the clinical laboratory. We have developed assays for the detection of Glyco-phosphatidyl-inositol (GPI)-linked structures that are lacking in Paroxysmal Nocturnal Hemoglobinuria and related disorders like Aplastic Anemia. I co-authored the recent ICCS Guidelines for the diagnosis of this PNH by flow cytometry. We have recently developed standardised highly sensitive flow assays to detect this disease on a variety of instrument types.
In 1996 this method evolved into a clinical Guideline for ISHAGE (Int’l Soc Hematotherapy and Graft Evaluation). The ‘single platform’ variant of the ISHAGE Guidelines is the most widely used method Worldwide to assess graft adequacy in the Bone Marrow Transplant setting and is embodied in several National and International Guidelines for graft assessment by Flow Cytometry. This work led to the Wallace H. Coulter Distinguished Lecture Award in 2006, “to recognize lifetime contribution to the science, education and practice of Clinical Cytometry.”
As Technical Director of the UHN Clinical Flow Cytometry Laboratory at Toronto General Hospital, I develop new Flow Cytometric assays for deployment in the clinical laboratory. We have developed assays for the detection of Glyco-phosphatidyl-inositol (GPI)-linked structures that are lacking in Paroxysmal Nocturnal Hemoglobinuria and related disorders like Aplastic Anemia. I co-authored the recent ICCS Guidelines for the diagnosis of this PNH by flow cytometry. We have recently developed standardised highly sensitive flow assays to detect this disease on a variety of instrument types.
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