Dr. Moerman’s highly successful research program has two distinct parts, which both take advantage of the genetic power of the model organism, C. elegans. The first focused on understanding muscle. His work centered on the roles of pivotal muscle proteins myosin, twitchin, titin, perlecan, and the kindlins, using classical structure and function analyses to understand their role in muscle development and function. In addition, he studied the organization of the genes that encode these proteins, and their expression patterns during C. elegans development. This work also allowed for the discovery and use of the transposon, tc1, which in its time, was a powerful genetic tool for the generation and identification of C. elegans mutants.