基本信息
浏览量:345
职业迁徙
个人简介
Our clinical research programme, emanating from our basic science studies, cross-cuts the research themes of Cardiovascular and Imaging, and involves active collaborations across the Academic Health Sciences Partnership and other London hospital Trustee below. Based directly on our preclinical observations, we are currently investigating new and specific treatment strategies for reducing myocardial injury and improving clinical outcomes in patients with CHD, focusing on those AMI patients undergoing percutaneous coronary intervention (PCI) and patients undergoing coronary artery bypass graft (CABG) surgery. These new treatment strategies include: (1) Remote ischaemic conditioning (RIC), which describes the cardioprotection obtained from inducing brief ischaemia-reperfusion to the upper limb, using a blood pressure cuff applied to the upper arm. Paramedics from LAS have been administering the RIC protocol to AMI patients in the ambulance. We have recently demonstrated that RIC reduces myocardial injury in CABG patients - we now intend to determine whether RIC can improve clinical outcomes in CABG patients in a London-wide multicentred study; (2) Erythropoietin (EPO), a haemopoietic agent, which is capable of reducing myocardial infarct size by 40-50% through the activation of the RISK pathway. (3) Cyclosporin-A (CsA). We are organising an Europe-wide multi-centred clinical study to determine whether CsA can improve clinical outcomes in AMI patients undergoing PPCI. We will be assessing cardioprotection in AMI patients in terms of myocardial infarct size, microvascular obstruction, and LV function using cardiac MRI.
研究兴趣
论文共 898 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF CELLULAR AND MOLECULAR MEDICINEno. 6 (2024): e18152-e18152
Molecular genetics and metabolismno. 4 (2023): 107552-107552
HEART (2023): A307-A307
引用0浏览0引用
0
0
Strokeno. 8 (2023): 2204-2207
Journal of clinical medicineno. 13 (2023): 4291-4291
medRxiv (Cold Spring Harbor Laboratory) (2023)
Basic research in cardiologyno. 1 (2023): 22-9
Cardiovascular Drugs and Therapypp.1-5, (2023)
REDOX BIOLOGY (2023): 102894-102894
European Heart Journalno. Supplement_2 (2023)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn