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个人简介
My research interests are focused on developing novel methods for detecting, monitoring, and treating hematologic malignancies; particularly non-Hodgkin lymphomas (NHLs). I aim to create tools to rapidly detect and quantify tumors and their response to chemotherapy and immunotherapy, thereby enabling personalized therapies. Toward this end, I utilize tools from a wide range of disciplines, including bioengineering, computational biology, and medical oncology. I previously implemented high-throughput sequencing of the immunoglobulin genes from plasma cell-free DNA for detection of diffuse large B cell and follicular lymphomas (DLBCL and FL), the two most common types of lymphoma. This work demonstrated the superior efficacy of this assay from cell-free DNA as compared to circulating white blood cells, and has led to its translation to the clinic. Recently, I have implemented targeted next-generation sequencing for ultra-sensitive detection of circulating tumor DNA utilizing Cancer Personalized Profiling by Deep Sequencing, or CAPP-Seq, for use in NHLs. This work has led to a number of important applications in the field, including early detection of disease relapse, non-invasive genotyping of tumors, and detection of transformation of follicular lymphoma into DLBCL.
研究兴趣
论文共 141 篇作者统计合作学者相似作者
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Ruwan Gunaratne,Crystal Zhou,Jesse W. Tai,Matthew Schwede, Kailee Tanaka, Matthew Alkaitis,Raymond Yin,Brian J. Sworder,Gabriel Mannis,Ravindra Majeti,Michael S. Khodadoust,David M. Kurtz,
Hematological Oncologyno. S2 (2023): 214-216
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BLOODno. Supplement 1 (2023): 4369-4369
Cédric Rossi,Jan Boegeholz,Stefan Alig, Adriana Garófolo,Mohammad Shahrokh Esfahani,Joseph Schroers‐Martin,Mari Olsen, Xiaonan Kang,David M. Kurtz, T. Sugio,Mark P. Hamilton,Marc André,
Hematological Oncologyno. S2 (2023): 321-322
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NEW ENGLAND JOURNAL OF MEDICINEno. 8 (2023): 764-766
Blood (2023): 3133
Blood (2023): 192
Lara Stepan, Sahar Ansari, Abood Okal, Justine Dell'Aringa,Ethan Thompson,Alessandro Crotta,Victor A Chow,Jeremy S. Abramson,Manali Kamdar,Jacob J. Chabon, Gregory Hogan,David M. Kurtz,
Blood (2023): 225
Hematological Oncologyno. S2 (2023): 524-525
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