David Thornton
教授
Division of Infection
Immunity & Respiratory Medicine, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester;Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester
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个人简介
Research in my laboratory is focused on understanding how the sticky, gel-like substance mucus protects the body. Research is focused on two major topics; • How does mucus protect our lungs? • How does mucus protect against gut-living parasitic worms? In the lungs, mucus is essential in keeping the airways free from obstruction. Mucus traps inhaled bugs and particles and then hair-like cells (cilia) move the mucus out of the lungs. In diseases like asthma, cystic fibrosis and chronic bronchitis too much mucus, which is stickier than normal, is produced and it is not efficiently removed from the lungs. This results in airflow obstruction, infection, damage to lung tissue and problems with breathing. We are trying to understand how mucins, the molecules that give mucus its gel-like appearance, contribute to the abnormal properties of mucus in disease. Infections by gut-living whipworms are a major public health problem, mainly in the developing world. For these studies we are using a mouse model of human whipworm infection. We discovered that the mucus barrier and its mucin components are an essential part of a well-coordinated response to protect against of gut-living worms. We are actively investigating the details of this important protective function.
研究兴趣
论文共 163 篇作者统计合作学者相似作者
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Alexander R. Bennett,Iris Mair,Andrew Muir,Hannah Smith,Larisa Logunova, Andrew Wolfenden,Jonathan Fenn,Ann E. Lowe,Janette E. Bradley,Kathryn J. Else,David J. Thornton
Scientific Reportsno. 1 (2024): 1-11
RESPIRATORY RESEARCHno. 1 (2023): 1-18
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Evelyn Funjika,Stefano A P Colombo,Kelly S Hayes, Mary J Tozer, Katrina A Tyrrell, Shanshan Cai,Aduragbemi A Faniyi,Rebecca K Shears, Megan Dooley, Yasmine Alshammari,Wafaa Alhazmi,Mushref Assas,
Gael Tavernier, Taqdees Qureshi, Furkan Zurel, Leanne Holmes,Lynn Elsey,David Thornton,Stephen Fowler,Thomas Pantin
EUROPEAN RESPIRATORY JOURNAL (2023)
Gael Tavernier, Taqdees Qureshi,Mathilde Volpato,Isabelle Vachier, Marion Wood, Furkan Zurel,David Thornton,Matthieu Robert De Saint Vincent,Jeremy Patarin,Robert Lord,Stephen Fowler,Jeremy Charriot
EUROPEAN RESPIRATORY JOURNAL (2023)
María A. Duque-Correa,David Goulding,Faye H. Rodgers,J. Andrew Gillis,Claire Cormie,Kate A. Rawlinson,Allison J. Bancroft,Hayley M. Bennett, Magda E. Lotkowska,Adam J. Reid,Anneliese O. Speak, Paul Scott,
biorxiv(2022)
A. Livraghi-Butrico,B. Grubb,J. Carpenter,S. Danielsen,M. Markovetz,G. Chen, G. Radicioni, A. Saldana-Montavon,L. Sun, M. Gutay, J. Vilar,C. Ehre,
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2022): S23-S26
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