David Harrison
教授
Department of Pharmacology
School of Medicine, Vanderbilt University;Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University;Division of Clinical Pharmacology, Vanderbilt University Medical Center;Department of Medicine, Vanderbilt University Medical Center
关注
立即认领
分享
关注
立即认领
分享
基本信息
浏览量:8
职业迁徙
个人简介
His research laboratory has been focused on understanding how inflammation, and in particular, the adaptive immune response contributes to hypertension. Several years ago, they found that T cells are essential for the development of hypertension. His lab has shown that various hypertensive stimuli, including angiotensin II, norepinephrine and DOCA-salt cause activation of T cells and leads to their accumulation in the perivascular fat and kidneys. The data indicates that T cell-derived cytokines such as IL-17 and TNF-a enhance vasoconstriction and sodium retention, leading to the hypertensive phenotype. Central signals derived from the circumventricular organs contribute to T cell activation, and manipulation of signals from this region affect T cell activation and the eventual elevation in blood pressure caused by angiotensin II.
研究兴趣
论文共 1235 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Hypertension (Dallas, Tex. : 1979)no. 5 (2024): e44-e46
Circulation researchno. 1 (2024): 30-32
Nature reviews. Nephrologypp.1-11, (2024)
D. G. Harrison, M. Bader, L. O. Lerman, G. Fink, S. A. Karumanchi, J. F. Reckelhoff, M. L. S. Sequeira-Lopez, R. M. Touyz
Hypertension (Dallas, Tex. : 1979)no. 1 (2024): 3-5
Journal of the Royal Society of Medicineno. 5 (2023): 1410768231172151-166
Nutrition, metabolism, and cardiovascular diseases : NMCDno. 7 (2023): 1398-1406
Celestine N. Wanjalla, J. Aaron Simmons,Jared Oakes, Xiuqi Zhang, Cindy Nochowivz,Stephen Priest,Samuel Bailin, Christopher M Watten,Mona Mashayekhi,Heather K. Beasley,Jian Wang,Leslie M. Meenderink,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Gwenyth J. Joseph,Lawrence A. Vecchi,David Kell,Sasidhar Uppuganti,Margaret Durdan, Wei Chen,David Harrison,Jeffry S. Nyman, Megan Weivoda,Rachelle W. Johnson
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 53-53
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn