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The surface region of a biomaterial is the interface between that material and the biological environment. Thus, the surface structure and composition of a biomaterial mediates the biological reactions that occur when biomaterials are placed into the body. Our research is directed at obtaining detailed information about the surface composition and structure of biomaterials and the interaction of biomolecules with those biomaterials. Recent advances in biochemistry and biomaterials have made it possible to control chemistry on a local scale undreamed of only a few years ago. The dimensions of the lateral chemical variations are diminishing, the complexity of the molecules being introduced at the surface is increasing, and the manipulations of the surface moieties become ever more sophisticated. These advances offer great challenges and opportunities for biomedical surface analysis.
Experimental methods we use in our research include x-ray photoelectron spectroscopy (XPS, also known as ESCA), static time-of-flight secondary ion mass spectrometry (ToF-SIMS), scanning force microscopy (SFM), near edge x-ray adsorption spectroscopy (NEXAFS), sum frequency generation (SFG) vibrational spectroscopy and surface plasmon resonance (SPR). Current research projects include the characterization of model biomaterial systems (self-assembled monolayers, peptides, ordered proteins, etc.), the development of chemical state imaging methods, and characterization of immobilized proteins. The objective of these research projects is to improve our understanding of the relationship between the surface properties of a biomaterial and the biological reactions occurring on that material by determining, in detail, the composition, structure, spatial distribution, and orientation of surface species.
Experimental methods we use in our research include x-ray photoelectron spectroscopy (XPS, also known as ESCA), static time-of-flight secondary ion mass spectrometry (ToF-SIMS), scanning force microscopy (SFM), near edge x-ray adsorption spectroscopy (NEXAFS), sum frequency generation (SFG) vibrational spectroscopy and surface plasmon resonance (SPR). Current research projects include the characterization of model biomaterial systems (self-assembled monolayers, peptides, ordered proteins, etc.), the development of chemical state imaging methods, and characterization of immobilized proteins. The objective of these research projects is to improve our understanding of the relationship between the surface properties of a biomaterial and the biological reactions occurring on that material by determining, in detail, the composition, structure, spatial distribution, and orientation of surface species.
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JOURNAL OF VACUUM SCIENCE & TECHNOLOGY Ano. 2 (2024): 023416-023416
Biointerphasesno. 3 (2023)
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SENSORS AND ACTUATORS B-CHEMICAL (2021): 129452-129452
Biomaterials Sciencepp.53-75, (2020)
CHARACTERIZATION OF NANOPARTICLES: MEASUREMENT PROCESSES FOR NANOPARTICLESpp.295-347, (2020)
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