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Proteases and protease nexins: regulation of neural cells
Over the past fifteen years, Dr. Cunningham and his colleagues have identified and studied two protease inhibitors called protease nexins (PNs) that regulate certain proteases in the extracellular environment. The PNs are synthesized and secreted by a variety of extravascular cells including fibroblasts, smooth muscle cells, neurons and astrocytes. They bind and inhibit certain serine proteases by forming a complex with their catalytic site serine residue. The complexes bind back to the cells and are rapidly internalized and degraded. This provides a mechanism for regulating and clearing serine proteases in the extracellular environment. This localized regulatory mechanism is well suited for the brain because the blood brain barrier prevents plasma protease inhibitors from entering the brain.
Proteases and protease nexins: regulation of neural cells
Over the past fifteen years, Dr. Cunningham and his colleagues have identified and studied two protease inhibitors called protease nexins (PNs) that regulate certain proteases in the extracellular environment. The PNs are synthesized and secreted by a variety of extravascular cells including fibroblasts, smooth muscle cells, neurons and astrocytes. They bind and inhibit certain serine proteases by forming a complex with their catalytic site serine residue. The complexes bind back to the cells and are rapidly internalized and degraded. This provides a mechanism for regulating and clearing serine proteases in the extracellular environment. This localized regulatory mechanism is well suited for the brain because the blood brain barrier prevents plasma protease inhibitors from entering the brain.
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Ciba Foundation Symposium - Growth Control in Cell CulturesNovartis Foundation Symposiapp.207-220, (2008)
mag(2002)
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Dennis D Cunningham, Frances M Donovan
mag(1997)
mag(1995)
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