基本信息
浏览量:43
职业迁徙
个人简介
Research Focus
Aging is the progressive accumulation of damaged macromolecules and cellular structures that negatively impair tissue homeostasis. As a multifactorial biological process, aging inevitably affects organismal fitness and increases susceptibility to infectious and chronic illness, including neurodegenerative diseases. With a demographic shift toward a population with more elderly people, it becomes imperative to develop novel long-term effective strategies that help to ameliorate age-related disorders. Over the last years, exciting studies have described a wide range of pharmacological, dietary and genetic interventions that can promote longevity of multicellular organisms. Given their positive effect on health and stress resistance, the underlying lifespan-extending signaling pathways may be promising targets for treatment of age-related chronic illnesses. Our laboratory explores the interplay between epigenetics, mitochondrial function and metabolism in aging and neurodegenerative disorders. As part of our program, we focus on metabolic changes that occur in animals carrying mitochondrial lesions. Furthermore, we study those epigenetic regulators that promote transcriptional flexibility underlying lifespan-extending programs and environment-induced metabolic adaptations. Our final goal is to define the relevance of these factors in the onset and progression of neurodegenerative processes. Additionally, using genetic and pharmacological approaches, we aim to unveil molecular targets and perform proof-of-principle compound screenings with potential applications in preclinical studies.
Activities in the Scientific Community / Professional Memberships
Since 2010 Receiving Editor of Cell Death and Disease
Honors and Awards
2000 and 2001 Ing.Aldo Gini fellowship (Fondazione Ing.Aldo Gini, University of Padova)
2001 EMBO fellowship (EMBO)
2007 Research loan from the University of Zurich (University of Zurich)
Aging is the progressive accumulation of damaged macromolecules and cellular structures that negatively impair tissue homeostasis. As a multifactorial biological process, aging inevitably affects organismal fitness and increases susceptibility to infectious and chronic illness, including neurodegenerative diseases. With a demographic shift toward a population with more elderly people, it becomes imperative to develop novel long-term effective strategies that help to ameliorate age-related disorders. Over the last years, exciting studies have described a wide range of pharmacological, dietary and genetic interventions that can promote longevity of multicellular organisms. Given their positive effect on health and stress resistance, the underlying lifespan-extending signaling pathways may be promising targets for treatment of age-related chronic illnesses. Our laboratory explores the interplay between epigenetics, mitochondrial function and metabolism in aging and neurodegenerative disorders. As part of our program, we focus on metabolic changes that occur in animals carrying mitochondrial lesions. Furthermore, we study those epigenetic regulators that promote transcriptional flexibility underlying lifespan-extending programs and environment-induced metabolic adaptations. Our final goal is to define the relevance of these factors in the onset and progression of neurodegenerative processes. Additionally, using genetic and pharmacological approaches, we aim to unveil molecular targets and perform proof-of-principle compound screenings with potential applications in preclinical studies.
Activities in the Scientific Community / Professional Memberships
Since 2010 Receiving Editor of Cell Death and Disease
Honors and Awards
2000 and 2001 Ing.Aldo Gini fellowship (Fondazione Ing.Aldo Gini, University of Padova)
2001 EMBO fellowship (EMBO)
2007 Research loan from the University of Zurich (University of Zurich)
研究兴趣
论文共 73 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Amyotrophic lateral sclerosis & frontotemporal degenerationno. 1-2 (2024): 135-149
Yushuang Deng, Avadh Kumar,Kan Xie,Kristina Schaaf,Enzo Scifo, Sarah Morsy, Tao Li, Armin Ehninger,Daniele Bano,Dan Ehninger
Cell death discoveryno. 1 (2024): 217-217
Joshua Jackson,Christian Hoffmann,Enzo Scifo, Han Wang,Lena Wischhof,Antonia Piazzesi,Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B Ryan,Hermann Döring,
Cell death & diseaseno. 4 (2024): 304-304
Roberto Sansevrino,Christian Hoffmann,Jian-Hua Chen, Johannes Vincent Tromm,Joshua Jackson,Mark Le Gros,Daniele Bano,Carolyn Larabell,Dragomir Milovanovic
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. 29 Suppl 1 (2023): 1157-1157
Mechanisms of ageing and development (2023): 111837-111837
Cell death and differentiationno. 5 (2023): 1097-1154
Massimo Vetralla,Lena Wischhof, Vanessa Cadenelli,Enzo Scifo,Dan Ehninger,Rosario Rizzuto,Daniele Bano,Diego De Stefani
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cell death discoveryno. 1 (2023): 1-4
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn