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Hafler, in many respects, is credited with identifying the central mechanisms underlying the likely cause of MS. His early seminal work demonstrated that the disease began in the blood, not the brain, which eventually led to the development of Tysabri to treat the disease by blocking the movement of immune cells from the blood to the brain. He was the first to identify myelin-reactive T cells in the disease, published in Nature, showing that indeed, MS was an autoimmune disorder. He then went on to show why autoreactive T cells were dysregulated by the first identification of regulatory T cells in humans followed by demonstration of their dysfunctional state in MS. As a founding, Broad Institute member, Hafler identified the genes that cause MS, published in the New England Journal of Medicine and Nature. More recently, he identified the key transcription factors and signaling pathways associated with MS genes as potential treatment targets. Finally, he recently discovered that salt drives induction of these pathogenic myelin reactive T cells, both works published in Nature. Hafler was the Breakstone Professor of Neuroscience at Harvard, and became Chairman of Neurology at Yale in 2009, where he has built an outstanding clinical and research program that strongly integrates medical sciences. He has received numerous honors including the Dystel Prize from the AAN for his MS research and is among the most highly cited living neurologists and is a member of the National Academy of Medicine.
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Nature Reviews Immunologypp.1-15, (2024)
Jessica Wei, Jeonghyeon Moon, Yoshiaki Yasumizu,Le Zhang, Khadir Radassi, Nicholas Buitrago-Pocasangre,M Elizabeth Deerhake, Nicholas Strauli, Alan Chan,Ann Herman, Rosetta Pedotte,Catarina Raposo,
bioRxiv : the preprint server for biology (2024)
Jessica Wei,Jeonghyeon Moon,Yoshiaki Yasumizu,Le Zhang, Khadir Radassi, Nicholas Buitrago-Pocasangre,M. Elizabeth Deerhake, Nicolas Strauli, Alan Chan,Ann Herman, Rosetta Pedotti,Catarina Raposo,
biorxiv(2024)
David Hafler,Benjamin Lu,Liliana Lucca, Wesley Lewis, Jiping Wang, Catarina Nogeuira,Sebastian Heer,Pierre-Paul Axisa, Nicholas Buitrago-Pocasangre, Giang Pham, Mina Kojima,Wei Wei,
Research square (2024)
Beatriz F Côrte-Real,Ibrahim Hamad,Rebeca Arroyo Hornero,Sabrina Geisberger, Joris Roels,Lauren Van Zeebroeck,Aleksandra Dyczko,Marike W van Gisbergen,Henry Kurniawan,Allon Wagner,Nir Yosef, Susanne N Y Weiss,
GENOME BIOLOGYno. 1 (2023): 1-17
Dongjoo Kim,Giulia Biancon,Zhiliang Bai,Jennifer VanOudenhove,Yuxin Liu,Shalin Kothari,Lohith Gowda,Jennifer M. Kwan, Nicholas Carlos Buitrago‐Pocasangre,Nikhil Lele,Hiromitsu Asashima, Michael K. Racke,
Small Methodsno. 10 (2023)
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Le Zhang, Chuan Hua He,Sarah Coffey, Dominic Yin,I-Uen Hsu,Chang Su,Yixuan Ye,Chi Zhang,Joshua Spurrier,LaShae Nicholson,Carla V Rothlin,Sourav Ghosh,
medRxiv : the preprint server for health sciences (2023)
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