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Description of Research Expertise
KEYWORDS & TECHNIQUES:
Cancer Biology, Adaptive Stress Responses, mRNA Translation, Drug targeting, Protein Homeostasis, CRISPR Screen, Ribosome Profiling, Proteomics, in vivo and ex vivo models
Insights into the genetic landscape of patient samples have depicted an explosion of diagnostic and clinical biomarkers using gene expression profiling. However, not all changes at the transcription level translate into proteomic expression, thus limiting the predictive power of mRNA-based prognostics. Genetic alterations also remain difficult to target pharmacologically, and many oncogenes play roles for normal cellular functions which prevents their targeting. Despite these limitations, there arise phenotypic vulnerabilities that malignant cells rely on for their survival.
Dr. Conn's research program is focused on understanding:
1) the signaling pathways that are activated in cancer cells allowing for their dynamic adaptations to stress (nutrient, proteomic, oxidative...etc) during cellular transformation and disease progression
2) how aggressive cancer cells rewire their translational machinery to select distinct mRNAs for protein expression, while 3) identifying unique isoforms created through non-conventional initiation and the functions they serve
4) the relevance of the above processes towards disease detection, improved therapeutical targeting and treatments, with an underlying goal for prevention.
ROTATION PROJECTS:
Starting 2021, please contact Dr. Conn to inquire
KEYWORDS & TECHNIQUES:
Cancer Biology, Adaptive Stress Responses, mRNA Translation, Drug targeting, Protein Homeostasis, CRISPR Screen, Ribosome Profiling, Proteomics, in vivo and ex vivo models
Insights into the genetic landscape of patient samples have depicted an explosion of diagnostic and clinical biomarkers using gene expression profiling. However, not all changes at the transcription level translate into proteomic expression, thus limiting the predictive power of mRNA-based prognostics. Genetic alterations also remain difficult to target pharmacologically, and many oncogenes play roles for normal cellular functions which prevents their targeting. Despite these limitations, there arise phenotypic vulnerabilities that malignant cells rely on for their survival.
Dr. Conn's research program is focused on understanding:
1) the signaling pathways that are activated in cancer cells allowing for their dynamic adaptations to stress (nutrient, proteomic, oxidative...etc) during cellular transformation and disease progression
2) how aggressive cancer cells rewire their translational machinery to select distinct mRNAs for protein expression, while 3) identifying unique isoforms created through non-conventional initiation and the functions they serve
4) the relevance of the above processes towards disease detection, improved therapeutical targeting and treatments, with an underlying goal for prevention.
ROTATION PROJECTS:
Starting 2021, please contact Dr. Conn to inquire
研究兴趣
论文共 21 篇作者统计合作学者相似作者
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Cell metabolismno. 3 (2023): 517-534.e8
Jiajie Wei,Rigel J. Kishton,Matthew Angel,Crystal S. Conn, Nicole Dalla-Venezia,Virginie Marcel,Anne Vincent,Frédéric Catez,Sabrina Ferré, Lilia Ayadi,Virginie Marchand,Devin Dersh,
semanticscholar(2019)
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