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My lab is interested in how genes can be selectively inactivated and how the silent state can be perpetuated through multiple rounds of cell division, and even from one generation to the next. One longstanding interest of the lab is the uniparental silencing of 45S ribosomal RNA (rRNA) genes in genetic hybrids, an epigenetic phenomenon known as nucleolar dominance. 45S rRNA genes are transcribed in the nucleolus by RNA polymerase I. There are thousands of nearly identical rRNA genes in the genome. At specific periods of development, most or all of these rRNA genes are presumably needed, but in most cell types the number of rRNA genes exceeds the physiological demands of the cell. Under these conditions, excess rRNA genes are selectively inactivated via mechanisms that involve methylation of the DNA and chemical modifications of the histone proteins that organize the DNA. My student and postdoctoral colleagues in the lab are working to understand the mechanisms responsible for selective rRNA gene silencing, focusing on new evidence that the silencing decisions are not made one rRNA gene at a time but are made on a multi-megabase, sub-chromosomal scale affecting hundreds of rRNA genes.
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Weiyi Li, Stephan Baehr,Michelle Marasco, Lauren Reyes,Danielle Brister,Craig S. Pikaard,Jean-Francois Gout,Marc Vermulst,Michael Lynch
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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The Plant journal : for cell and molecular biologyno. 5 (2023): 1185-1192
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Gireesha Mohannath,Anastasia McKinlay, Navinchandra Venkata Puppala,Ramya Enganti,Gargi Prasad Saradadevi,Todd Blevins,Craig Pikaard
biorxiv(2023)
Science advancesno. 44 (2023)
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