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The research in my lab is centered on intracellular quality control mediated by autophagy ("self-eating"), a lysosomal degradation pathway essential for nutrient recycling, cellular maintenance and physiological function. Autophagy is induced by stress conditions such as fasting and exercise, and allows cells to adapt to changing nutrient and energy demands through protein catabolism. Our interest focuses on the roles and mechanisms of autophagy in the regulation of metabolism and in the pathogenesis of metabolic and neurological disorders, including obesity, type 2 diabetes, neurodegeneration, and drug abuse. Malfunction of autophagy is implicated in a variety of diseases, such as metabolic disorders, neurodegeneration, cancer, infection and aging; conversely, we have shown that upregulation of autophagy mediates exercise-induced metabolic benefits and protects Alzheimer’s mice from neurodegeneration. We are also interested in demonstrating how the autophagy machinery recognizes various cargos for catabolic metabolism, including aggregate-prone proteins, secretory proteins and membrane receptors, in metabolic organs and in different neuronal cell types in the brain, and studying how such degradation leads to metabolic and behavioral alterations.
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论文共 65 篇作者统计合作学者相似作者
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CELL METABOLISMno. 4 (2023): 620-+
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Xianxiu Qiu,Na Li,Qifan Yang,Shuai Wu,Xiaohua Li, Xuehua Pan,Soh Yamamoto,Xiaozhe Zhang,Jincheng Zeng, Jiahao Liao,Congcong He,Renxiao Wang,
Autophagyno. 11 (2023): 2884-2898
Ruifan Wu,Jooman Park,Yanyu Qian, Zuoxiao Shi, Ruoci Hu,Yexian Yuan,Shaolei Xiong,Zilai Wang,Gege Yan,Sang-Ging Ong,Qing Song,Zhenyuan Song,
crossref(2022)
Autophagy in Health and Diseasepp.9-19, (2022)
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