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个人简介
Colin received a Bachelor of Pharmacy degree in 1959 and
a Doctorate in Medicinal Chemistry in 1962, both from the
University of London, United Kingdom. He came to NIH as a
Visiting Fellow in 1962. From 1965 to 1968, he was one of the
first NIGMS Research Associates in Pharmacology and Toxicology (now called the Pharmacology Research in Toxicology,
PRAT Program). In 1977, Colin moved to the National Institute
of Environmental Health Sciences, where he held a variety of
scientific and administrative positions that included Chief of
the Laboratory of Environmental Biophysics and the Laboratoryof Molecular Biophysics, as well as acting Scientific Director.
As Chief of the Laboratory of Molecular Biophysics, he
recruited all three of the principal investigators trained in
physical chemistry who are presently at NIEHS.
In his professional career, Colin was at the forefront of a
revolution in pharmacology that sought to understand the
molecular basis of pharmacological activity. He appreciated the
critical importance of technological innovations for elucidation
of the molecular interactions that form the basis for therapeutic
efficacy as well as adverse toxicological reactions. One of
Colin’s most significant insights was an appreciation that the
inherent photolability and photoreactivity of many pharmacological
agents and xenobiotics meant that a full understanding
of the health effects would require photochemical as well as
more conventional biochemical and biological evaluations. His
specific research interests included the investigation of the
photosensitization reactions (phototoxicity and/or photoallergy)
that occur in exposed tissues such as the skin and eyes due to
the reaction of ultraviolet and/or visible radiation with endogenous
and exogenous chemical agents that form singlet oxygen
and free radicals. His group used a variety of molecular biology
approaches as well as sophisticated spectroscopic techniques
such as fluorescence, phosphorescence, electron spin resonance,
and laser and conventional flash photolysis in these studies. He
published over 220 peer-reviewed articles in leading biomedical
journals, as well as more than 30 book chapters and reviews,
including at least nine publications in 2008. In 1973, he was
awarded the John J. Abel “The Father of American Pharmacology” prize by the American Society for Pharmacology and
Experimental Therapeutics. Recently, he was named Associate
Editor of the Journal of Photochemistry and Photobiology.
Dr. Chignell was an outstanding, internationally recognized
scientist who made major contributions to the fields of free
radical biology and medicine and molecular toxicology. However,
he will be best remembered by his colleagues at NIEHS
for his impressively high scientific and administrative integrity
and his fair treatment of others. He was a valued and readily
accessible colleague who had a broad knowledge of chemical
and biochemical topics. His managerial style was always
nurturing and supportive, never overbearing, and he never tried
to impose his will on the objectives or operation of the individual
research groups under his supervision. Moreover, he treated
everyone in the same fair, supportive, and friendly manner,
regardless of their station. He was an inspiring supervisor to
students and postdoctoral fellows from countries around the
globe. For many, the training and research expertise obtained
in Dr. Chignell’s laboratory was the foundation to the successful
development of their careers as scientists.
Colin was an accomplished professional, a dedicated scientist,
an effective mentor, and a talented organizer. He was a highly
principled person and a beloved figure at NIEHS who will be
greatly missed by his many friends and colleagues.
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Free Radical Biology and Medicineno. 9 (2009): 1260-6
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