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个人简介
We are currently pursuing 3 main research streams:
Investigating the role of lesional macrophage proliferation in atherosclerosis. Which process - monocyte influx or macrophage proliferation - is more important? What are the mechanisms that drive proliferation? How does the balance between the two processes change with co-morbidities and treatment? Does one process influence the other? Which of the two is the better therapeutic target? The answers to these question are likely to identify new therapeutic targets in treating atherosclerosis.
Determining the contribution of embryonic- versus bone marrow-derived macrophages in atherosclerosis. Some macrophages develop from hematopoietic stem cells, while others develop prior to birth and independent of the bone marrow. We ask the important question whether functional differences exist between these different macrophage populations and to what extent each population contributes to disease.
Determining the molecular mechanisms that regulate macrophage accumulation in atherosclerosis. In addition to growth factors, hematopoiesis is tightly controlled at the transcriptional level. One such transcription factor, c-Myb, has been demonstrated to play an important role in the survival, proliferation, and differentiation of hematopoietic cells. We are currently studying the role of c-Myb in regulating inflammation atherosclerosis.
Investigating the role of lesional macrophage proliferation in atherosclerosis. Which process - monocyte influx or macrophage proliferation - is more important? What are the mechanisms that drive proliferation? How does the balance between the two processes change with co-morbidities and treatment? Does one process influence the other? Which of the two is the better therapeutic target? The answers to these question are likely to identify new therapeutic targets in treating atherosclerosis.
Determining the contribution of embryonic- versus bone marrow-derived macrophages in atherosclerosis. Some macrophages develop from hematopoietic stem cells, while others develop prior to birth and independent of the bone marrow. We ask the important question whether functional differences exist between these different macrophage populations and to what extent each population contributes to disease.
Determining the molecular mechanisms that regulate macrophage accumulation in atherosclerosis. In addition to growth factors, hematopoiesis is tightly controlled at the transcriptional level. One such transcription factor, c-Myb, has been demonstrated to play an important role in the survival, proliferation, and differentiation of hematopoietic cells. We are currently studying the role of c-Myb in regulating inflammation atherosclerosis.
研究兴趣
论文共 93 篇作者统计合作学者相似作者
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Nature Immunologyno. 5 (2023): 743-745
crossref(2022)
CIRCULATIONno. 18 (2022): 1434-1436
Idit Dotan,Jiaqi Yang,Jiro Ikeda, Ziv Roth,Evan Pollock-Tahiri, Harsh Desai,Tharini Sivasubramaniyam,Sonia Rehal, Josh Rapps,Yu Zhe Li,Helen Le, Gedaliah Farber,
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