My laboratory's research focus involves the application of modern genomics and bioinformatics approaches to unravel complex and rare cardiovascular diseases. By integrating large-scale human genetic association and whole genome sequencing data with multi-omic profiles and clinically-relevant models, our work seeks to better understand causal disease mechanisms. We are dissecting the role of genetic and drug perturbations on vascular wall processes during atherosclerosis progression. We are also studying gene-gene and gene-environment interactions at the molecular level to further inform translational targeting of multiple risk loci.