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My research has been focussed on the function of GSLs in normal and pathophysiology, in particular on how the variable lipid moiety and its membrane environment affects function. Early work on GSL binding in spermatogenesis lead to assays which defined the GSL receptor for verotoxin (VT, shiga toxin). We found this GSL (Gb3) played a key role in VT-induced hemolytic uremic syndrome(E.coli hamburger disease). Gb3 was increased in many human cancers and their neovasculature and proposed VT as a novel antineoplastic. The male germ cell work also defined a GSL binding for hsp 70. Our development of the chemistry to generate water soluble GSL-adamantane conjugates which retained membrane receptor function, lead to a sulfogalactosyl ceramide-derived inhibitor of hsp70 and a Gb3-based inhibitor of HIV. Current work is directed to generation of a drug-like version of the latter.
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EUROPEAN JOURNAL OF BIOCHEMISTRYno. 2 (2004): 405-417
Annals of the New York Academy of Sciences (1978): 160-77
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