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Human obesity is predominantly a disease of brain pathways regulating appetite. Our aim is to help characterize these pathways to eventually develop safe and efficient therapies promoting satiety.
Although protein is known to be the most potent appetite suppressant among all macronutrients, little is known about how the mammalian brain senses protein availability to create neural representations that guide behaviour and modulate metabolism. Data obtained across taxa from flies to humans indicate that evolutionary-conserved homeostatic mechanisms tightly control protein intake, and that this control is prioritized over the control of carbohydrate, fat or energy intake. Targeting protein-sensing mechanisms could therefore represent a novel avenue for the development of anti-obesity drugs.
Human obesity is predominantly a disease of brain pathways regulating appetite. Our aim is to help characterize these pathways to eventually develop safe and efficient therapies promoting satiety.
Although protein is known to be the most potent appetite suppressant among all macronutrients, little is known about how the mammalian brain senses protein availability to create neural representations that guide behaviour and modulate metabolism. Data obtained across taxa from flies to humans indicate that evolutionary-conserved homeostatic mechanisms tightly control protein intake, and that this control is prioritized over the control of carbohydrate, fat or energy intake. Targeting protein-sensing mechanisms could therefore represent a novel avenue for the development of anti-obesity drugs.
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American journal of physiology. Endocrinology and metabolismno. 4 (2024): E472-E480
Emma Roth,Simon Benoit, Baptiste Quentin,Brian Lam,Sarah Will,Marcella Ma, Nick Heeley,Tamana Darwish, Yashaswi Shrestha,Fiona Gribble,Frank Reimann,Irina Pshenichnaya,
bioRxiv (2020): 101070-28
Alice E Adriaenssens,Emma K Biggs,Tamana Darwish,John Tadross,Tanmay Sukthankar, Milind Girish,Joseph Polex-Wolf, Brain Y Lam,Ilona Zvetkova,Warren Pan,Davide Chiarugi,Giles S H Yeo,
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