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个人简介
We are interested in lipid metabolism and how it promotes atherosclerosis in the setting of obesity, insulin resistance and diabetes. Our work is translational, spanning cultured cells, animal models and humans.
Fats are partitioned to tissues in highly regulated ways. Excess lipids directed to adipose tissue are stored and lead to obesity, a disorder associated with diabetes, insulin resistance, and heart disease. We engineered mice with ectopic and inducible expression of uncoupling protein-1 (UCP-1) in specific tissues. UCP-1 is an inner mitochondrial anion transporter that uncouples respiration and oxidative phosphorylation. These animals are being used to study the role of metabolism in age-related diseases such as atherosclerosis and hypertension.
Fats are partitioned to tissues in highly regulated ways. Excess lipids directed to adipose tissue are stored and lead to obesity, a disorder associated with diabetes, insulin resistance, and heart disease. We engineered mice with ectopic and inducible expression of uncoupling protein-1 (UCP-1) in specific tissues. UCP-1 is an inner mitochondrial anion transporter that uncouples respiration and oxidative phosphorylation. These animals are being used to study the role of metabolism in age-related diseases such as atherosclerosis and hypertension.
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American journal of physiology. Cell physiologyno. 4 (2024): C1034-C1041
Samantha E Adamson,Sangeeta Adak,Max C Petersen, Dustin Higgins,Larry D Spears, Rong Mei Zhang, Andrea Cedeno,Alexis McKee, Aswathi Kumar, Sudhir Singh,Fong-Fu Hsu,Janet B McGill,
Journal of lipid researchno. 3 (2024): 100519-100519
Rodrigo Meade, Yang Chao,Nikolai Harroun, Chenglong Li, Shahab Hafezi,Fong-Fu Hsu,Clay F. Semenkovich,Mohamed A. Zayed
JVS - Vascular Science (2023): 100181-100181
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Research Square (Research Square) (2023)
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The American journal of pathologyno. 12 (2023): 2144-2155
Arteriosclerosis, Thrombosis, and Vascular Biologyno. Suppl_1 (2023): 100138
Saba R Aliyari,Amir Ali Ghaffari,Olivier Pernet,Kislay Parvatiyar,Yao Wang,Hoda Gerami,Ann-Jay Tong,Laurent Vergnes, Armin Takallou, Adel Zhang,Xiaochao Wei,Linda D Chilin,
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