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Research interests
My research focus is on trying to understand the mechanisms behind upsurges in disease caused by the human pathogen Streptococcus pyogenes (also known as group A Streptococcus). Upsurges occur frequently and can be associated with specific genotypes.
I use a combination of whole genome sequencing, epidemiology, clinical analysis and phenotypic work to try and identify what makes strains successful at causing disease and become suddenly more abundant.
One of my particular interests is recombination-related genome remodelling, which we identified to be the driving force behind a very recent shift in the population of the S. pyogenes genotype emm89. A new variant of emm89 emerged from the population having undergone six regions of recombination within the core genome.
This recombination-related genome remodelling led to substantial phenotype changes, including loss of the hyaluronic acid capsule and increase of toxin expression, altering the way this genotype interacted with the host.
The emergent variant has now become the dominant form of emm89 in the UK and globally, causing a high level of disease. Understanding how recombination occurs and what the impact of recombination is on the bacterium are part of my research aims.
研究兴趣
论文共 65 篇作者统计合作学者相似作者
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Edwin P Armitage, Gabrielle de Crombrugghe, Alexander J Keeley, Elina Senghore, Fatoumata E Camara, Musukoi Jammeh, Amat Bittaye, Haddy Ceesay, Isatou Ceesay, Bunja Samateh, Muhammed Manneh,Beate Kampmann,
The Lancet Microbe (2024)
Jennifer N. Hall,Edwin P. Armitage,Elina Senghore,Saffiatou Darboe, Momodou Barry, Janko Camara,Sulayman Bah, Alexander J. Keeley,James S. McCarthy,Pierre Smeesters,Claire E. Turner,Thomas C. Darton,
medrxiv(2024)
Jennifer N Hall,Saikou Y Bah,Henna O Khalid, Alison Brailey, Sarah Coleman, Tracey Kirk, Naveed Hussain, Mark Tovey,Roy R Chaudhuri, Steve Davies, Lisa Tilley,Thushan de Silva,
crossref(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Ho Kwong Li,Xiangyun Zhi,Ana Vieira,Harry J. Whitwell, Amelia Schricker,Elita Jauneikaite,Hanqi Li, Ahmed Yosef, Ivan Andrew,Laurence Game,Claire E. Turner,Theresa Lamagni,
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Erin A. Catton,Daniel A. Bonsor,Carolina Herrera, Margaretha Stalhammar-Carlemalm,Mykola Lyndin,Claire E. Turner, Jo Soden,Jos A. G. van Strijp,Bernhard B. Singer,Nina M. van Sorge,Gunnar Lindahl,Alex J. McCarthy
NATURE COMMUNICATIONSno. 1 (2023)
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Luke R. R. Green,Rahaf Issa, Fawzyah Albaldi,Lucy Urwin, Ruth Thompson,Henna Khalid,Claire E. E. Turner,Barbara Ciani,Lynda J. J. Partridge,Peter N. N. Monk
biorxiv(2023)
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