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Our research interests fall within the general area of host-parasite interactions, and specifically the ability of gastrointestinal (GI) helminth parasites to modify the structure and function of the host gut flora to their advantage. In particular, our research focuses on identifying the immune-molecular mechanisms that underpin the observed chmicrobiota make-up of helminth-infected humans and animals. The consequences that elucidating such mechanisms may exert on future strategies of parasite control are two-fold. First, disentangling the potential contribution of the gut flora to the pathogenesis of the infection is necessary in order to discover and develop new strategies to contrast helminth-associated pathology. Second, understanding the microbiota-dependent mechanisms by which parasitic helminths are able to modulate host immune responses and suppress inflammation may assist the discovery of novel immune-regulatory therapeutics against chronic inflammatory disorders of the GI tract that may act in synergy with helminth-based therapy.
研究兴趣
论文共 178 篇作者统计合作学者相似作者
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Parasites & Vectorsno. 1 (2024): 1-16
Maria Francesca Sini,Maria Manconi,Antonio Varcasia, Giovanna Massei, Ramona Sandu,Naunain Mehmood,Fahad Ahmed, Carlo Carta,Cinzia Cantacessi,Christian Scarano,Antonio Scala,Claudia Tamponi
Scientific Reportsno. 1 (2024): 1-11
Trends in Parasitologyno. 5 (2023): 402-402
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Maria Francesca Sini, Maria Manconi,Antonio Varcasia,Giovanna Massei, Ramona Luminița Sandu,Naunain Mehmood,Fahad Ahmed,Carlo Carta,Cinzia Cantacessi,Christian Scarano,Antonio Scala,Claudia Tamponi
Research Square (Research Square) (2023)
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The Journal of infectious diseases (2023)
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