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The 25-member Kadoch Laboratory, located at the Dana-Farber, uses multidisciplinary approaches to unravel chromatin and gene regulatory mechanisms, including biochemistry, biophysics, structural biology, human genetics, genomics, epigenomics, and systems and computational biology. We focus on large protein complexes known as ATP-dependent chromatin remodeling complexes, with emphasis on the mammalian SWI/SNF (mSWI/SNF) family, which play critical roles in governing genomic architecture and gene expression. These macromolecular machines are among the most diverse and heterogeneous enzyme-driven entities encoded by the mammalian genome, each containing a central catalytic ATPase member along with additional subunits that play specialized structural or functional roles to enable alteration of DNA-nucleosome contacts. The genes encoding chromatin remodeling complex components are frequently mutated in disease, with mammalian SWI/SNF (mSWI/SNF) complex subunits disrupted in >20% of human cancers as well as several neurodevelopmental disorders, often as sole genetic drivers, making them the most frequently perturbed chromatin regulatory family profiled to date. Such compelling and rapidly expanding human genetics coupled with an incomplete understanding and unmet biochemical challenges has inspired our comprehensive studies in to the structure and function of mammalian chromatin remodelers. Our work to date has informed new mechanistic principles of this broadly important cellular machinery in health and disease, providing requisite foundations for the development of new therapeutic approaches.
研究兴趣
论文共 136 篇作者统计合作学者相似作者
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Jessica Diane St. Laurent, Grace Xu, Alexander Ying, Bengul Gokbayrak,Ajinkya Patil,Akshay Sankar, Chae Young Shin,Daniel Same Guerra,David Kolin,David Huntsman,Yemin Wang,Cigall Kadoch
Cancer Researchno. 6_Supplement (2024): 1243-1243
Leslie Duplaquet, Kevin So, Alexander W Ying, Xinyue Li,Yixiang Li,Xintao Qiu, Rong Li, Shilpa Singh,Xiaoli S Wu, Qi Liu,Jun Qi,Tim D D Somerville,
bioRxiv : the preprint server for biology (2024)
Weicheng Li, Enrique M Garcia-Rivera,Dylan C Mitchell, Joel M Chick,Micah Maetani, John M Knapp, Geoffrey M Matthews,Ryosuke Shirasaki, Ricardo de Matos Simoes, Vasanthi Viswanathan,John L Pulice, Matthew G Rees,
bioRxiv : the preprint server for biology (2024)
Elena Battistello, Kimberlee Hixon,Dawn E. Comstock,Clayton K. Collings,Xufeng Chen,Javier Rodríguez Hernáez,Soobeom Lee,Konstantinos Ntatsoulis,Annamaria Cesarano, Kathryn Hockemeyer,W. Nicholas Haining,Matthew T Witkowski,
Cancer Researchno. 7_Supplement (2023): 1794-1794
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Ajinkya Patil,Amy R. Strom,Joao A. Paulo,Clayton K. Collings,Kiersten M. Ruff,Min Kyung Shinn,Akshay Sankar, Kasey S. Cervantes,Tobias Wauer,Jessica D. St. Laurent, Grace Xu,Lindsay A. Becker,
CELLno. 22 (2023): 4936-+
Nature geneticsno. 8 (2023): 1400-1412
Cancer Researchno. 7 (2023): 3485-3485
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Elena Battistello, Kimberlee Hixon,Dawn E. Comstock,Clayton K. Collings,Xufeng Chen, Javier Rodriguez Hernaez,Soobeom Lee, Konstantinos Ntatsoulis,Annamaria Cesarano, Kathryn Hockemeyer,W. Nicholas Haining,Matthew T. Witkowski,
CANCER RESEARCHno. 7 (2023)
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