My research focuses on the structural mechanisms and drug discovery in Alzheimer’s disease (AD), Hedgehog signaling and p53 in cancer, which have tremendous impact on human health. In AD, we are studying the structural mechanisms of the generation of amyloid-β peptide (Aβ). We also study the interaction between glycan and tau, which facilitates the spread of tau pathology, neurofibrillary tangle (NFT, the other pathological hallmark of AD). Another focus is the mechanisms of ApoE isoform which modulates AD risk. In cancer, we are studying the structural mechanism of Hedgehog signaling and p53 interactions.