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1. New genetic tools for the human microbiota. We have developed the first CRISPR-Cas9 based genetic system for a Clostridium commensal Clostridium sporogenes. We are interested in applying the CRISPR-Cas9 technology to other gut bacteria that have shown a strong correlation with human health and disease but are currently not genetically tractable.
2. Modulating microbiota metabolites in the host and study their effects on host biology. An increasing number of studies are revealing important connections between microbiome-derived metabolites and human diseases like inflammatory bowel disease and colon cancer. We will focus on a group of molecules that are derived via microbial fermentation of nutrients (e.g. propionate and butyrate). These molecules are highly abundant and circulatory (have body-wide effects) in the body and their levels can be manipulated via genetic engineering of the gut microbiome. We will apply the genetic tools in the lab to toggle on/off these microbiota metabolites in vivo and investigate their effects on host intestinal immunity and IBD development.
3. Regulating the metabolic interaction between host and gut microbiota. The microbiome is one of the key orchestrators in mediating human health. We will use bioinformatics and molecular genetics to design and engineer a microbiota community for a predefined function in regulating host intestinal immunity for IBD treatment.
2. Modulating microbiota metabolites in the host and study their effects on host biology. An increasing number of studies are revealing important connections between microbiome-derived metabolites and human diseases like inflammatory bowel disease and colon cancer. We will focus on a group of molecules that are derived via microbial fermentation of nutrients (e.g. propionate and butyrate). These molecules are highly abundant and circulatory (have body-wide effects) in the body and their levels can be manipulated via genetic engineering of the gut microbiome. We will apply the genetic tools in the lab to toggle on/off these microbiota metabolites in vivo and investigate their effects on host intestinal immunity and IBD development.
3. Regulating the metabolic interaction between host and gut microbiota. The microbiome is one of the key orchestrators in mediating human health. We will use bioinformatics and molecular genetics to design and engineer a microbiota community for a predefined function in regulating host intestinal immunity for IBD treatment.
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Ting-Ting Li, Xi Chen, Da Huo,Mohammad Arifuzzaman, Shanshan Qiao,Wen-Bing Jin, Huiqing Shi,Xin V. Li,Iliyan D. Iliev,David Artis,Chun-Jun Guo
Svetlana F Lima,Silvia Pires, Amanda Rupert, Seun Oguntunmibi,Wen-Bing Jin,Andrew Marderstein,Gabriela Funez-dePagnier, Grace Maldarelli,Monica Viladomiu,Gregory Putzel, Wei Yang, Nancy Tran,
Cell reports. Medicineno. 3 (2024): 101431-101431
Mohammad Arifuzzaman,Tae Hyung Won,Hiroshi Yano, Jazib Uddin, Elizabeth R Emanuel, Elin Hu,Wen Zhang,Ting-Ting Li,Wen-Bing Jin,Alex Grier,Sanchita Kashyap,Chun-Jun Guo,
The Journal of experimental medicineno. 5 (2024)
IMMUNITYno. 1 (2024): 14-27
Jingjing Cong, Pianpian Liu, Zili Han, Wei Ying,Chaoliang Li, Yifei Yang, Shuling Wang,Jianbo Yang,Fei Cao,Juntao Shen, Yu Zeng,Yu Bai,
Immunity (2024)
Katherine Z Sanidad,Stephanie L Rager, Hannah C Carrow,Aparna Ananthanarayanan,Ryann Callaghan, Lucy R Hart,Tingting Li, Purnima Ravisankar,Julia A Brown,Mohammed Amir, Jenny C Jin, Alexandria Rose Savage,
Science immunologyno. 93 (2024): eadj4775-eadj4775
Takato Kusakabe,Woan-Yu Lin,Jin-Gyu Cheong,Gagandeep Singh,Arjun Ravishankar,Stephen T. Yeung,Marissa Mesko, Meghan Bialt DeCelie, Guilhermina Carriche,Zhen Zhao,Sophie Rand,Itai Doron,
Nature immunologyno. 11 (2023): 1879-1889
bioRxiv : the preprint server for biology (2023)
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