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个人简介
Research-at-a-glance:
A programming language for cells
Engineering cellular sensors
Organelle refactoring and engineering
Genome-scale design
Engineering unusual organisms with unique capabilities
Genetic engineering is undergoing a revolution, where next-generation technologies for DNA and host manipulation are enabling larger and more ambitious projects in biotechnology. Automated DNA synthesis has advanced to where it is routine to order sequences >100,000bp where every base is user-specified, the turnaround time is several weeks, and the cost is rapidly declining. Recently, this facilitated the synthesis of a complete 1 Mbp genome of a bacterium and its transfer into a new host, resulting in a living cell. However, while whole genomes can be constructed, the ability to design such systems is lagging. The focus of my lab is to develop new experimental and theoretical methods to push the scale of genetic engineering, with the ultimate objective of genome design. This will impact the engineering of biology for a broad range of applications, including agriculture, materials, chemicals, and medicine.
A programming language for cells
Engineering cellular sensors
Organelle refactoring and engineering
Genome-scale design
Engineering unusual organisms with unique capabilities
Genetic engineering is undergoing a revolution, where next-generation technologies for DNA and host manipulation are enabling larger and more ambitious projects in biotechnology. Automated DNA synthesis has advanced to where it is routine to order sequences >100,000bp where every base is user-specified, the turnaround time is several weeks, and the cost is rapidly declining. Recently, this facilitated the synthesis of a complete 1 Mbp genome of a bacterium and its transfer into a new host, resulting in a living cell. However, while whole genomes can be constructed, the ability to design such systems is lagging. The focus of my lab is to develop new experimental and theoretical methods to push the scale of genetic engineering, with the ultimate objective of genome design. This will impact the engineering of biology for a broad range of applications, including agriculture, materials, chemicals, and medicine.
研究兴趣
论文共 181 篇作者统计合作学者相似作者
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Shuyi Zhang, Ziyuan Ma, Wenjie Li, Yunhao Shen, Yunxin Xu, Gengjiang Liu, Jiamin Chang, Zeju Li, Hong Qin, Boxue Tian, Haipeng Gong,David Liu,
Research square (2024)
Alice Boo,Tyler Toth, Qiguo Yu,Alexander Pfotenhauer, Brandon D. Fields,Scott C. Lenaghan,C. Neal Stewart Jr,Christopher A. Voigt
Nature Communicationsno. 1 (2024): 1-16
biorxiv(2024)
Xuefei Angelina Nou,Christopher A. Voigt
Nature Chemical Biologyno. 2 (2024): 211-220
Alexander J. Triassi, Brandon D. Fields,Catherine E. Monahan, Jillian M. Means,Yongjin Park,Hamid Doosthosseini, Jai P. Padmakumar,Vincent M. Isabella,Christopher A. Voigt
Cell Systemsno. 6 (2023): 512-+
Nature Catalysisno. 11 (2023): 1016-1029
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Nature microbiologyno. 12 (2023): 2420-2434
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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ACS synthetic biologyno. 4 (2023): 1119-1132
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