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The late Professor Sir Christopher Dobson died on 8th September 2019. Chris was not only a world-class researcher whose work helped to advance the global understanding of conditions such as Alzheimer’s and Parkinson’s diseases, but also a kind and compassionate man who encouraged many aspiring scientists and built a wide network of collaborators in this research field. (You can see his obituary on our website here.) Although he has died, the research described below continues within the Centre for Misfolding Diseases, part of the Chemistry of Health building – a state-of-the-art facility for the study of neurodegenerative diseases that he was instrumental in creating.
Our research interests are primarily focused on the investigation of the structures and properties of biological molecules, especially proteins, and their relationship to biological evolution and disease. We have particular interest in the fundamental science underlying disorders such as Alzheimer's and Parkinson's disease. In addition, however, we have recently become involved in the novel utilisation of biological molecules in materials science and nanotechnology.
The methods we use are largely experimental, but do include theoretical and computational approaches. Much of the work is highly interdisciplinary, and people joining the group come from a wide variety of scientific backgrounds ranging from experimental biochemistry to theoretical physics. The research group is based in the Chemistry Department in a newly constructed laboratory located in the Unilever Building. The range of experimental techniques used by the group is very large, including NMR, EM, AFM and X-ray diffraction, as well as a variety of methods based on optical spectroscopy, including fluorescence and circular dichroism. Many, but not all, members of the group also use the techniques of protein chemistry and molecular biology.
The group has close links with scientists in other laboratories in Cambridge, including the Clinical School, the Genetics Department and the Nanoscience Centre and, indeed, some members of the group have been largely based in these departments. New members of the group usually develop a project by discussion with me, along with other members of the research team. Group members are often involved in joint projects with other laboratories and may spend periods of time working with our collaborators in other parts of the world.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 21 (2023)
Matthias M Schneider,Tom Scheidt, Ashley J Priddey,Catherine K Xu, Mengsha Hu,Georg Meisl, Sean R A Devenish,Christopher M Dobson, Vasilis Kosmoliaptsis,Tuomas P J Knowles
FRONTIERS IN MOLECULAR BIOSCIENCES (2022): 981312
user-5f8cf9244c775ec6fa691c99(2021)
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