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Our laboratory is interested in a family of transcriptional regulators known as PAS proteins. Members of this emerging family of proteins control a number of processes, including xenobiotic metabolism (Ah-receptor and Arnt), circadian rhythms (Per), angiogenesis (HIF1a and Arnt), and neurogenesis (Sim). The model system that is currently emphasized is the signal transduction pathway mediated by Ah-receptor/Arnt heterodimeric complex. These helix-loop-helix-PAS proteins regulate the induction of a number of xenobiotic metabolizing enzymes that occur in response to exposure to a variety of polycyclic aromatic environmental pollutants. In addition, the Ah-receptor mediates a second battery of genes responsible for a number of “toxic effects” of dioxins, such as epithelial hyperplasia, immunosuppression, teratogenesis, and tumor promotion.
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Emmanuel Vazquez-Rivera, Brenda Rojas, Jessica C Parrott,Anna L Shen,Yongna Xing,Patrick R Carney,Christopher A Bradfield
Emmanuel Vazquez-Rivera, Brenda L Rojas,Patrick R Carney, Jose L Marrero-Valentin,Christopher A Bradfield
R H Wilson,P R Carney, E Glover, J C Parrott, B L Rojas, S M Moran, J S Yee, M Nukaya, N A Goetz,C D Rubenstein,K J Krentz, Y Xing,
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