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Christopher McCulloch is a full professor in the Faculty of Dentistry, University of Toronto.
His primary appointment is Director of the Matrix Dynamics Group. The group currently consists of five principal investigators and focuses on the regulation of connective tissue matrix proteins in health and disease.
Dr McCulloch received a Career Scientist Award from the Ontario Ministry of Health (1984-1994), a Scientist Award from Columbia University (New York City), a Distinguished Alumnus Award from the Faculty of Dentistry, University of Toronto (2011), the Distinguished Scientist Award for Research in Oral Biology from the International Association of Dental Research (IADR) in 2009 and a Canada Research Chair (Tier 1) in Matrix Dynamics (2006-2020).
He has been a consultant for the Royal College of Dental Surgeons of Ontario (RCDSO) since 2006.
His research focuses on the remodelling of connective tissue matrices.
He initially established the location and proliferative behaviour of cells in the periodontal ligament and showed that subpopulations of these cells can undergo self-renewal, a characteristic of stem cells. He used actin isoform analyses to establish that alpha-smooth muscle actin is a differentiation marker for contractile fibroblasts from the periodontium and is required for collagen contraction.
Further, he has shown that the actin binding protein filamin A is required for protection of cells in mechanically active environments.
Finally, Chris has defined the role of collagen phagocytosis in connective tissue matrix remodeling and established the importance of this pathway for the formation of fibrotic lesions.
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