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The post-Human Genome Project era has highlighted the importance of environmental factors for the development of common human disorders, including metabolic, inflammatory, and neurodegenerative disease. Our goal is to decipher the mechanisms by which these environmental factors, including diet, the light-dark cycle, temperature, xenobiotics and physical activity, are integrated into host physiology. In particular, we study the molecular and cellular pathways of communication between the outside world and the metabolic, immune, and nervous system.
We are using systems biology tools (including single-cell transcriptomics, metagenomics, and metabolomics), coupled to hypothesis-driven research in animal models and human cohorts. Our ultimate goal is to develop innovate new therapies for common human diseases.
Of special interest is the role of the microbiome – the entirety of microorganisms colonizing the human host – as a mediator between the inside and outside world of the human organism. The composition and function of the microbiome is greatly shaped by lifestyle and environmental factors and a critical determinant of disease susceptibility. We are devising new tools to study the microbiome and its communication with other organs of the body.
We are recruiting interested scientists at all levels (rotation students, graduate students, postdocs, research assistants, technicians). For available projects, please contact Christoph Thaiss.
We are using systems biology tools (including single-cell transcriptomics, metagenomics, and metabolomics), coupled to hypothesis-driven research in animal models and human cohorts. Our ultimate goal is to develop innovate new therapies for common human diseases.
Of special interest is the role of the microbiome – the entirety of microorganisms colonizing the human host – as a mediator between the inside and outside world of the human organism. The composition and function of the microbiome is greatly shaped by lifestyle and environmental factors and a critical determinant of disease susceptibility. We are devising new tools to study the microbiome and its communication with other organs of the body.
We are recruiting interested scientists at all levels (rotation students, graduate students, postdocs, research assistants, technicians). For available projects, please contact Christoph Thaiss.
研究兴趣
论文共 89 篇作者统计合作学者相似作者
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biorxiv(2023)
Kai Markus Schneider,Niklas Blank,Yelina Alvarez, Katharina Thum,Patrick Lundgren,Lev Litichevskiy, Madeleine Sleeman,Klaas Bahnsen,Jihee Kim, Simon Kardo,Shaan Patel,Lenka Dohnalova,
CELLno. 13 (2023): 2823-+
Jordan C Harris,Natalie A Trigg, Bruktawit Goshu,Yuichi Yokoyama,Lenka Dohnalová, Ellen K White,Adele Harman,Christoph A Thaiss,Elizabeth A Grice,Colin C Conine,Taku Kambayashi
bioRxiv : the preprint server for biology (2023)
CLINICAL AND TRANSLATIONAL MEDICINEno. 10 (2023): n/a-n/a
Patrick Lundgren, Prateek V Sharma,Lenka Dohnalová,Kyle Coleman,Giulia T Uhr, Susanna Kircher,Lev Litichevskiy,Klaas Bahnsen,Hélène C Descamps,Christina Demetriadou, Jacqueline Chan,Karthikeyani Chellappa,
Nature metabolismno. 10 (2023): 1691-1705
Andrea Di Francesco,Andrew G. Deighan,Lev Litichevskiy,Zhenghao Chen, Alison Luciano,Laura Robinson, Gaven Garland, Hannah Donato, Will Schott,Kevin M. Wright,Anil Raj,G.V. Prateek,
biorxiv(2023)
Lev Litichevskiy, Maya Considine,Jasleen Gill, Vasuprada Shandar, Timothy O. Cox,Helene C. Descamps,Kevin M. Wright, Kevin R. Amses,Lenka Dohnalova, Megan J. Liou, Monika Tetlak, Mario R. Galindo-Fiallos,
biorxiv(2023)
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Jihee Kim,Kirti Nath,Kurt Schmidlin,Helen Schaufelberger, Christiana Quattropani, Simone Vannini, Sandro Mossi,Miriam Thumshirn,Michael Manz,Lev Litichevskiy,Jiaxin Fan,Oxana Dmitrieva-Posocco,
Science (New York, N.Y.)no. 6653 (2023): 38-38
NEUROPSYCHOPHARMACOLOGY (2023): 161-161
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