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职业迁徙
个人简介
Research Interests
Hepatitis B virus biology.
DNA repair mechanisms involved in hepatitis B virus replication.
Host factors required for the HBV life cycle.
Mechanisms for HBV persistence.
Lab Overview
We are interested in the biology of human pathogenic viruses with an emphasis on mechanisms of viral replication and host-virus interactions that play a role in innate immunity. Our investigations on hepatitis B virus (HBV) lead to the identification of the signals required for reverse transcription of the viral DNA and provided the basis for the current model for hepadnavirus replication. We discovered that the hepatitis B polymerase could be expressed in enzymatically active form in the presence of the heat shock protein 90 complex. Moreover, we demonstrated that recovery from chronic hepatitis B infections requires massive destruction of infected hepatocytes.
Hepatitis B virus biology.
DNA repair mechanisms involved in hepatitis B virus replication.
Host factors required for the HBV life cycle.
Mechanisms for HBV persistence.
Lab Overview
We are interested in the biology of human pathogenic viruses with an emphasis on mechanisms of viral replication and host-virus interactions that play a role in innate immunity. Our investigations on hepatitis B virus (HBV) lead to the identification of the signals required for reverse transcription of the viral DNA and provided the basis for the current model for hepadnavirus replication. We discovered that the hepatitis B polymerase could be expressed in enzymatically active form in the presence of the heat shock protein 90 complex. Moreover, we demonstrated that recovery from chronic hepatitis B infections requires massive destruction of infected hepatocytes.
研究兴趣
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Journal of virologyno. 10 (2023): e0118523-e0118523
LIVER: BIOLOGY AND PATHOBIOLOGY, 6TH EDITION, 6 EDITIONpp.795-820, (2020)
Molecular Biology of the Hepatitis B Viruspp.213-226, (2018)
Molecular Therapyno. 7 (2016): 1258-1266
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