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Christian Tschudi is the John Rodman Paul Professor of Epidemiology and Director of Graduate Studies at the Yale School of Public Health and earned an A.B. in microbiology and a Ph.D. in biochemistry from the University of Basel in Switzerland. He currently co-directs an NIH-sponsored Global Infectious Disease Training Program (D43) in translational research training on leishmaniasis & emerging infectious diseases and is the co-director of the China Scholarship Council-Yale World Scholars Program in Public Health. Dr. Tschudi is an expert on neglected tropical diseases, as evidenced by editorial board and study section appointments and a Burroughs Wellcome Award. He is currently the organizer of the international conference on kinetoplastid molecular cell biology. Dr. Tschudi’s studies focus on the biology of trypanosomes the causative agents of devastating diseases in Africa and South America with special emphasis on one of the fundamental steps in the life of a pathogen, namely the acquisition of infectivity.
Research Summary
Unraveling the biology of pathogens is fundamental toward understanding mechanisms of pathogenesis and identifying genes essential for survival in the host. Our research focuses on the protozoan parasite Trypanosoma brucei, which causes devastating diseases in humans and animals in sub-Saharan Africa. We are applying RNA interference (RNAi), namely down-regulation of gene expression by homologous double-stranded RNA, to identify genes essential for survival within the insect vector and mammalian host. In addition, high-throughput next-generation sequencing technologies (RNA-Seq) are used to analyze gene expression patterns (the transcriptome) during the developmental cycle. Lastly, we are interested in understanding gene silencing by RNAi in African trypanosomes with the objective to uncover its biological function.
Specialized Terms: African trypanosomiasis; Gene expression profiling; Gene discovery; Next-generation sequencing; RNA interference
Christian Tschudi is the John Rodman Paul Professor of Epidemiology and Director of Graduate Studies at the Yale School of Public Health and earned an A.B. in microbiology and a Ph.D. in biochemistry from the University of Basel in Switzerland. He currently co-directs an NIH-sponsored Global Infectious Disease Training Program (D43) in translational research training on leishmaniasis & emerging infectious diseases and is the co-director of the China Scholarship Council-Yale World Scholars Program in Public Health. Dr. Tschudi is an expert on neglected tropical diseases, as evidenced by editorial board and study section appointments and a Burroughs Wellcome Award. He is currently the organizer of the international conference on kinetoplastid molecular cell biology. Dr. Tschudi’s studies focus on the biology of trypanosomes the causative agents of devastating diseases in Africa and South America with special emphasis on one of the fundamental steps in the life of a pathogen, namely the acquisition of infectivity.
Research Summary
Unraveling the biology of pathogens is fundamental toward understanding mechanisms of pathogenesis and identifying genes essential for survival in the host. Our research focuses on the protozoan parasite Trypanosoma brucei, which causes devastating diseases in humans and animals in sub-Saharan Africa. We are applying RNA interference (RNAi), namely down-regulation of gene expression by homologous double-stranded RNA, to identify genes essential for survival within the insect vector and mammalian host. In addition, high-throughput next-generation sequencing technologies (RNA-Seq) are used to analyze gene expression patterns (the transcriptome) during the developmental cycle. Lastly, we are interested in understanding gene silencing by RNAi in African trypanosomes with the objective to uncover its biological function.
Specialized Terms: African trypanosomiasis; Gene expression profiling; Gene discovery; Next-generation sequencing; RNA interference
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PLoS pathogensno. 6 (2023): e1011438-e1011438
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