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个人简介
Dr. Larsen has made seminal contributions to the investigation of the immunologic mechanisms of transplant rejection and immunologic tolerance and is an internationally recognized leader in kidney and pancreas transplantation. He has been funded continuously by the NIH since 1996. The recipient of a prestigious NIH MERIT award, he has directed program project grants, center awards, and multi-institutional consortia.
With his long-time collaborator Dr. Thomas Pearson, Dr. Larsen initiated a transplant immunology research program that played a pivotal role in developing a new class of immunosuppressive drugs known as costimulation blockers. One such drug is belatacept, which Dr. Larsen, Dr. Pearson, and researchers at Bristol Myers Squibb began developing in the 1990s as a less toxic alternative to standard immunosuppressants. In 2011, the FDA approved belatacept in the form of the drug Nulojix for kidney transplant recipients. In 2015, the BENEFIT study, which was initiated in 2006 and led by Dr. Larsen and UCSF transplant specialist Dr. Flavio Vincenti, conclusively showed that belatacept had a better record of patient and organ survival than a calcineurin inhibitor.
With his long-time collaborator Dr. Thomas Pearson, Dr. Larsen initiated a transplant immunology research program that played a pivotal role in developing a new class of immunosuppressive drugs known as costimulation blockers. One such drug is belatacept, which Dr. Larsen, Dr. Pearson, and researchers at Bristol Myers Squibb began developing in the 1990s as a less toxic alternative to standard immunosuppressants. In 2011, the FDA approved belatacept in the form of the drug Nulojix for kidney transplant recipients. In 2015, the BENEFIT study, which was initiated in 2006 and led by Dr. Larsen and UCSF transplant specialist Dr. Flavio Vincenti, conclusively showed that belatacept had a better record of patient and organ survival than a calcineurin inhibitor.
研究兴趣
论文共 695 篇作者统计合作学者相似作者
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Jean L. Koff,Geeta M. Karadkhele, Jeffrey M. Switchenko,Manali Rupji,Kendra Little,Christian P. Larsen
Frontiers in Transplantation (2024)
Emily M Eichenberger, Maja Wichhart Donzo, Rebecca Anderson,Geeta Karadkhele,Stephanie M Pouch,Christian P Larsen
Clinical transplantationno. 3 (2024): e15279-e15279
Ahmed Babiker,Geeta Karadkhele,Andrei Bombin, Rockford Watkins,Chad Robichaux,Gillian Smith, Vivek B. Beechar, Danielle B. Steed, Jesse T. Jacobs,Timothy D. Read,Sarah Satola,Christian P. Larsen,
KIDNEY INTERNATIONAL REPORTSno. 12 (2023): 2529-2545
Brendan P Lovasik,Steven C Kim, Laura Higginbotham, Walter Wakwe,David V Mathews,Cynthia Breeden,Alton B Farris,Christian P Larsen,Mandy L Ford,Steven Nadler,Andrew B Adams
bioRxiv : the preprint server for biology (2023)
W. Magua,A.K. Okoh, P. Pranav, J. Wang,G. Karadkhele, R. Cole,M. Daneshmand, D. Gupta,C. Larsen, A. Morris
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