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Chris Wallace's research programme has three complementary aims. First, to develop the statistical tools needed to identify genetic associations with disease, then robustly and empirically link each genetic association with a gene, cell type, stimulatory condition and ultimately a biological pathway. Specifically, this requires methods for:
horizontal integration of different layers of omics data
mapping the variants which regulate gene expression
"fine mapping" causal genetic variants from amongst associated variants in genetic association data, typically using sparse variable selection
"fine mapping" regulatory contacts in 3D maps of folded DNA from technologies such as promoter capture Hi-C
horizontal integration of different layers of omics data
mapping the variants which regulate gene expression
"fine mapping" causal genetic variants from amongst associated variants in genetic association data, typically using sparse variable selection
"fine mapping" regulatory contacts in 3D maps of folded DNA from technologies such as promoter capture Hi-C
研究兴趣
论文共 226 篇作者统计合作学者相似作者
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Wei-Yu Lin, Melissa Kartawinata,Bethany R Jebson, Restuadi Restuadi, CLUSTER Consortium, Lucy R Wedderburn,Chris Wallace
biorxiv(2024)
Helen Ray-Jones, Zeji Song, Alexander Haglund, Pavel Artemov,Monica Della Rosa,Frances Burden,Roman Kreuzhuber, Anna Litovskikh, Vanessa Xue Hui Tan, Lai Ting Chan,Mattia Frontini,Chris Wallace,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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GUTno. SUPPL_3 (2023): A32-A33
Zenodo (CERN European Organization for Nuclear Research)no. 1 (2023)
biorxiv(2023)
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Christina T Stankey,Christophe Bourges, Tabitha Turner‐Stokes, Ana Pires Piedade, Christopher Palmer-Jones, Ilenia Papa,Mariana Silva dos Santos,Lyra O Randzavola,Leo Speidel, Eileen Parkes, William W. Edwards, A. Rochford,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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medRxiv : the preprint server for health sciences (2023)
COMMUNICATIONS BIOLOGYno. 1 (2023)
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Thomas W. Willis, Effrossyni Gkrania-Klotsa,Paul A. Lyons,Nicholas J. Wareham,Kenneth G. C. Smith,Eoin F. McKinney,Chris Wallace
HUMAN HEREDITYno. SUPPL 1 (2023): 65-65
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