基本信息
浏览量:1
职业迁徙
个人简介
Research interests
Chris’ research group (the One Health Microbiology laboratory) investigates the causes and consequences of bacterial persistence. Bacteria can persist in almost all environments due to their unprecedented ability to survive nutrient deprivation and resist antimicrobial treatment. To achieve this, environmental and pathogenic bacteria alike enter stress-resistant dormant states. One aim of the Greening Laboratory is to understand the metabolic processes that allow bacteria to stay energised and resist stresses in their dormant states. For example, they have shown that a wide range of bacteria switch from growing on organic sources to surviving on atmospheric trace gases such as hydrogen and carbon monoxide. In other words, they can live on air. Moreover, they have provided evidence that fermentation is a widespread mechanism of energy conservation, and revealed critical roles for cofactor F420 in mycobacterial persistence and drug resistance.
The Greening Laboratory also studies the consequences of microbial persistence across four major themes: global biodiversity, infectious disease, climate change, and public health. For example, bacteria that 'live on air' simultaneously control levels of climate-relevant atmospheric gases and enhance the resilience and productivity of soil ecosystems worldwide. A better understanding of these processes is critical to predict and mitigate greenhouse gas emissions and biodiversity loss. Many key pathogens, especially in the developing world, can persist for extended periods in environmental and host reservoirs. The Greening Laboratory are targeting the processes that enable Mycobacterium tuberculosis to survive in host tissues. The Greening Laboratory are also working within transdisciplinary research teams to combat childhood diarrhoea in Asia-Pacific communities; they aim to implement unified monitoring approaches, resolve transmission pathways, and develop scalable interventions to improve environmental conditions and human health.
The Greening Lab takes an interdisciplinary approach in order to understand biological processes at all levels of organisation: from enzymatic mechanisms to ecosystem importance. The benefits of an integrative microbiology approach are reflected by their work demonstrating the ubiquity of microbial hydrogen metabolism and multifaceted importance of mycobacterial F420 metabolism. To achieve this, they employ a versatile suite of bacteriology, molecular biology, microbial ecology, protein biochemistry, structural biology, systems biology, genomics, and biogeochemical approaches. They synergise the diverse expertise within the team and also collaborate with world experts in areas where they are non-experts. They are also chief investigators on three major applied programs that tackle key challenges in human health and sustainability. In each of these programs, we work with different researchers (e.g. clinicians, engineers, ecologists, social scientists) and stakeholders (e.g. communities, industry, government, hospitals) to facilitate translation of fundamental research into applied practice.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yingchun Han,Yongyi Peng, Jiaxue Peng,Lei Cao, Yangru Xu,Yi Yang,Minghuo Wu,Hao Zhou,Chen Zhang,Dongdong Zhang,Minxiao Wang,Chris Greening,
biorxiv(2024)
Trends in Microbiology (2024)
Tess F. Hutchinson,Adam J. Kessler,Wei Wen Wong, Puspitaningsih Hall,Pok Man Leung,Thanavit Jirapanjawat,Chris Greening,Ronnie N. Glud,Perran L. M. Cook
ISME JOURNALno. 1 (2024)
Microbiomeno. 1 (2024): 1-20
Pok Man Leung,Rhys Grinter, Eve Tudor-Matthew, James P. Lingford,Luis Jimenez, Han-Chung Lee, Michael Milton,Iresha Hanchapola, Erwin Tanuwidjaya,Ashleigh Kropp, Hanna A. Peach,Carlo R. Carere,
Qiushuang Li,Zhiyuan Ma, Jiabin Huo,Xiumin Zhang,Rong Wang, Shizhe Zhang,Jinzhen Jiao,Xiyang Dong,Peter H. Janssen,Emilio M. Ungerfeld,Chris Greening,Zhiliang Tan,
ISME JOURNALno. 1 (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Environment International (2023): 107962-107962
引用1浏览0WOS引用
1
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn