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个人简介
Research Interests:
The central theme of Dr. Fang's research is to investigate the structure-function relationships of biomolecules and novel materials, ranging from fluorescent proteins which can light up subcellular entities for bioimaging, proteins and enzymes that are potential targets for biomedicine, to nanoclusters and metal-organic complexes in solution. The interplay between chemistry, physics, and biology greatly facilitates ultrafast spectroscopic advances in the molecular vibration domain, which include FSRS (femtosecond stimulated Raman spectroscopy) annd 2D IR (two-dimensional infrared spectroscopy). The real-time structural snapshots of molecules "in action" offer unprecedented mechanistic insights on the intrinsic molecular timescale (10 fs - 1 ps) critical for their specific functions. In particular, photoswitchable and calcium-sensing fluorescent proteins are studied by FSRS to reveal the atomic choreography of the "flexible" chromophore inside the protein pocket upon photoexcitation and calcium ion binding. Functional motions of photoacids and other photosensitive materials during chemical reactions in condensed phase will also be elucidated.
The central theme of Dr. Fang's research is to investigate the structure-function relationships of biomolecules and novel materials, ranging from fluorescent proteins which can light up subcellular entities for bioimaging, proteins and enzymes that are potential targets for biomedicine, to nanoclusters and metal-organic complexes in solution. The interplay between chemistry, physics, and biology greatly facilitates ultrafast spectroscopic advances in the molecular vibration domain, which include FSRS (femtosecond stimulated Raman spectroscopy) annd 2D IR (two-dimensional infrared spectroscopy). The real-time structural snapshots of molecules "in action" offer unprecedented mechanistic insights on the intrinsic molecular timescale (10 fs - 1 ps) critical for their specific functions. In particular, photoswitchable and calcium-sensing fluorescent proteins are studied by FSRS to reveal the atomic choreography of the "flexible" chromophore inside the protein pocket upon photoexcitation and calcium ion binding. Functional motions of photoacids and other photosensitive materials during chemical reactions in condensed phase will also be elucidated.
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Nan Chieh Chiu, Jacob M. Lessard,Emmanuel Nyela Musa, Logan S. Lancaster, Clara Wheeler,Taylor D. Krueger,Cheng Chen,Trenton C. Gallagher,Makenzie T. Nord,Hongliang Huang,Paul Ha-Yeon Cheong,Chong Fang,
Yiming Sui, Alexis Scida,Bo Li,Cheng Chen, Yanke Fu, Yanzhao Fang,Peter Alex Greaney, Tomas Osborn Popp,De-En Jiang,Chong Fang, Xiulei Ji
Angewandte Chemie (International ed. in English)pp.e202401555-e202401555, (2024)
Physical chemistry chemical physics : PCCPno. 23 (2023): 15624-15634
JOURNAL OF MATERIALS CHEMISTRY C (2023)
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Nature Sustainabilityno. 7 (2023): 806-815
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