基本信息
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职业迁徙
个人简介
My goal is to find genetic predictors of disease that are useful for diagnosis, treatment, and understanding the disease’s biology. Traditionally, complex diseases like Alzheimer’s disease are studied through genome-wide association studies ( GWAS). However, conventional GWAS have failed to find a significant share of those genetic causes. I am interested in closing this gap by researching machine learning methods that extract more information from GWAS. Specifically, I superimpose GWAS information onto biological networks. Then, I explore such networks considering both the statistical association of each genetic factor - obtained from GWAS - and the biological context - obtained from the network. However, there are many open questions about how to do this, for instance:
How to exactly integrate GWAS information with networks?
What is the right strategy to find truly associated genetic factors? Which underlying assumptions are justified?
What sources of information should we consider when building those networks?
What is the suitable resolution? The SNP? The gene? The pathway?
With my multidisciplinary background in machine learning, statistical genetics, and biochemistry, I believe I am in a privileged position to tackle such questions
Interests
Genetics & heritability
Machine learning
Biological networks
Multi-omics integration
Multidisciplinary research
How to exactly integrate GWAS information with networks?
What is the right strategy to find truly associated genetic factors? Which underlying assumptions are justified?
What sources of information should we consider when building those networks?
What is the suitable resolution? The SNP? The gene? The pathway?
With my multidisciplinary background in machine learning, statistical genetics, and biochemistry, I believe I am in a privileged position to tackle such questions
Interests
Genetics & heritability
Machine learning
Biological networks
Multi-omics integration
Multidisciplinary research
研究兴趣
论文共 18 篇作者统计合作学者相似作者
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Markus Hoffmann, Julian M Poschenrieder,Massimiliano Incudini, Sylvie Baier, Amelie Fitz,Andreas Maier,Michael Hartung, Christian Hoffmann, Nico Trummer,Klaudia Adamowicz, Mario Picciani, Evelyn Scheibling,
medRxiv (Cold Spring Harbor Laboratory) (2023)
STAR PROTOCOLSno. 1 (2023): 101998-101998
bioRxiv (Cold Spring Harbor Laboratory) (2020)
Diane Duroux,Héctor Climente-González,Lars Wienbrandt,Kristel Van Steen, Ilias Maglogiannis,Lazaros Iliadis, Elias Pimenidis
AIAI (1)pp.128-140, (2020)
Héctor Climente-González,Christine Lonjou,Fabienne Lesueur, GENESIS Study collaborators,Dominique Stoppa-Lyonnet,Nadine Andrieu,Chloé-Agathe Azencott
biorxiv(2020)
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