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He contributed to the understanding of the function of the Myc oncogene, commonly altered in many cancers. His laboratory established a mechanistic link between Myc and cellular energy metabolism, which sparked the concept that genetic alterations could lead to metabolic reprogramming within tumors. His research provided evidence that aberrant cancer cell signaling pathways stimulated by various mutations exhibit dependence for specific nutrients to drive further proliferation. These observations have been heralded for helping to explain the “Warburg Effect” observed in cancer cells and have led to subsequent studies dedicated to the targeted disruption of aberrant cell metabolic pathways and developing drugs to inhibit cancer progression.
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论文共 324 篇作者统计合作学者相似作者
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Journal of clinical oncology : official journal of the American Society of Clinical Oncologyno. 1 (2024): 116-+
biorxiv(2023)
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Juliana Cazarin, Rachel E. DeRollo, Siti Noor Ahmad Shahidan, Jamison B. Burchett, Daniel Mwangi,Saikumari Krishnaiah, Annie L. Hsieh,Zandra E. Walton,Rebekah Brooks,Stephano S. Mello,Aalim M. Weljie,Chi Van Dang,
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