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Dr. Cheng pioneered the development of mouse models to understand the molecular basis of diseases due to mutations of thyroid hormone receptors. Her intensive studies of mouse models of hypothyroidism and resistance to thyroid hormone resulted in the discovery that mutations of thyroid hormone receptor subtypes lead to different human diseases. She also is elucidating the roles of thyroid hormone receptors in cancers. Dr. Cheng also developed preclinical mouse models of metastatic follicular thyroid cancer and anaplastic thyroid cancer. She focuses on the elucidation of altered signaling pathways to understand the molecular genetics underlying thyroid carcinogenesis. She identified molecular targets for potential treatment of thyroid cancer.
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论文共 183 篇作者统计合作学者相似作者
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Takahito Kimura,Woo Kyung Lee Doolittle, Michael Kruhlak,Li Zhao,Eunmi Hwang,Xuguang Zhu,Binwu Tang,Karen M. Wolcott,Sheue-yann Cheng
THYROIDno. 4 (2024): 484-495
ENDOCRINOLOGYno. 5 (2024)
Endocrine-related cancer (2023)
Endocrine-related Cancerno. 6 (2023)
FRONTIERS IN ENDOCRINOLOGY (2023): 1223976-224
Oncogeneno. 41 (2023): 3075-3086
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