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个人简介
Dr. Chen's Research focuses on the genetic control of vertebrate organogenesis. His particular interests include the role of homeobox genes and growth factors in the epithelial-mesenchymal interactions that lead to organ formation. One major project studies molecular mechanisms of tooth initiation and patterning. Currently, the project involves identifying genes involved in vertebrate tooth initiation and their expression regulation, studying the origin of tooth developmental potential, studying the patterning of incisor and molar teeth and genes involved in this process and studying the molecular basis of recombinant tooth formation (a model for tooth regeneration). Dr. Chen's research also studies the molecular basis of non-syndromic cleft palate caused by gene mutations in mammals. Cleft palate is one of the most frequent congenital birth defects in human being. It occurs annually with a frequency of 1 in 700 to 1,000 live births among individuals of European descent. Non-syndromic cleft palate arises from genetic or environmental perturbation in the multi-step process of palate development. Similar to human beings, mutations in the Msx1 gene cause non-sydromic cleft palate in mice. The lab is currently examining the role of Msx1, Dlx1, Dlx2, Bmps, Shh and Fgfs in mouse palatogenesis. Dr. Chen's work includes research on the molecular basis of situs inversus in vertebrate animals. Situs inversus occurs with a frequency of one out of 8,000 live births in humans. It was just recently demonstrated that positioning of internal organs is regulated by a cascade of genetic pathways involving a number of genes. Dr. Chen's lab has been studying the role of transcription factor Pitx2 in the regulation of heart looping. They have recently cloned two novel genes in the chick that show a potential involvement in left-right asymmetric determination during early embryonic development. Functional analyses of these two genes are in progress.
研究兴趣
论文共 1052 篇作者统计合作学者相似作者
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Xi Zheng, Xiaoying Chen,Xiaoxiao Hu,Lidan Chen, Nana Mi, Qianqian Zhong, Linfang Wang,Chensheng Lin,Yiping Chen,Fancai Lai,Xuefeng Hu,Yanding Zhang
JOURNAL OF PATHOLOGYno. 3 (2024): 320-333
Hua Li,Qinghuang Tang,Tianfang Yang,Zhengsen Wang,Dainan Li,Linyan Wang,Liwen Li, Yaoyi Chen,Hai Huang,Yanding Zhang,YiPing Chen
Communications biologyno. 1 (2024): 385-385
Therapeutic Apheresis and Dialysisno. 4 (2023): 720-725
BMC pediatricsno. 1 (2023): 264-8
International Journal of Biological Sciencesno. 15 (2023): 4833-4833
Development (Cambridge, England)no. 10 (2023)
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Yiping Chen,Risheng Yu,Joseph F X DeSouza, Yuze Shen,Hanyun Zhang, Chunpeng Zhu,Peiyu Huang,Caihua Wang
Frontiers in psychiatry (2023): 1184797
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Wenlong Nan,Mingxia Gong, You Lu,Jinming Li,Lin Li,Hailong Qu,Chunju Liu, Ying Wang, Faxing Wu,Xiaodong Wu,Zhiliang Wang,Yiping Chen,
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